Think Beyond the Core : Impact of the Hydrophilic Corona on Drug Solubilization Using Polymer Micelles

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Pysyväisosoite

http://hdl.handle.net/10138/330611

Lähdeviite

Haider , M S , Luebtow , M M , Endres , S , Forster , S , Flegler , V J , Boettcher , B , Aseyev , V , Pöppler , A-C & Luxenhofer , R 2020 , ' Think Beyond the Core : Impact of the Hydrophilic Corona on Drug Solubilization Using Polymer Micelles ' , ACS Applied Materials & Interfaces , vol. 12 , no. 22 , pp. 24531-24543 . https://doi.org/10.1021/acsami.9b22495

Julkaisun nimi: Think Beyond the Core : Impact of the Hydrophilic Corona on Drug Solubilization Using Polymer Micelles
Tekijä: Haider, Malik Salman; Luebtow, Michael M.; Endres, Sebastian; Forster, Stefan; Flegler, Vanessa J.; Boettcher, Bettina; Aseyev, Vladimir; Pöppler, Ann-Christin; Luxenhofer, Robert
Tekijän organisaatio: Department of Chemistry
Polymers
Päiväys: 2020-06-03
Kieli: eng
Sivumäärä: 13
Kuuluu julkaisusarjaan: ACS Applied Materials & Interfaces
ISSN: 1944-8244
DOI-tunniste: https://doi.org/10.1021/acsami.9b22495
URI: http://hdl.handle.net/10138/330611
Tiivistelmä: Polymeric micelles are typically characterized as core-shell structures. The hydrophobic core is considered as a depot for hydrophobic molecules, and the corona-forming block acts as a stabilizing and solubilizing interface between the core and aqueous milieu. Tremendous efforts have been made to tune the hydrophobic block to increase the drug loading and stability of micelles, whereas the role of hydrophilic blocks is rarely investigated in this context, with poly(ethylene glycol) (PEG) being the gold standard of hydrophilic polymers. To better understand the role of the hydrophilic corona, a small library of structurally similar A-B-A-type amphiphiles based on poly(2-oxazoline)s and poly(2-oxazine)s is investigated by varying the hydrophilic block A utilizing poly(2-methyl-2-oxazoline) (pMeOx; A) or poly(2-ethyl-2-oxazoline) (pEtOx; A*). In terms of hydrophilicity, both polymers closely resemble PEG. The more hydrophobic block B bears either a poly(2-oxazoline) and poly(2-oxazine) backbone with C3 (propyl) and C4 (butyl) side chains. Surprisingly, major differences in loading capacities from A-B-A > A*-B-A > A*-B-A* is observed for the formulation with two poorly water-soluble compounds, curcumin and paclitaxel, highlighting the importance of the hydrophilic corona of polymer micelles used for drug formulation. The formulations are also characterized by various nuclear magnetic resonance spectroscopy methods, dynamic light scattering, cryogenic transmission electron microscopy, and (micro) differential scanning calorimetry. Our findings suggest that the interaction between the hydrophilic block and the guest molecule should be considered an important, but previously largely ignored, factor for the rational design of polymeric micelles.
Avainsanat: poly(2-oxazoline)s
amphiphilic block copolymers
hydrophobic drugs
nanoformulations
corona-drug interactions
SOLID DISPERSION
DELIVERY-SYSTEMS
ORAL DELIVERY
COPOLYMER
POLY(2-OXAZOLINE)S
CURCUMIN
PEG
DOXORUBICIN
MORPHOLOGY
NANOPARTICLES
116 Chemical sciences
Vertaisarvioitu: Kyllä
Tekijänoikeustiedot: unspecified
Pääsyrajoitteet: openAccess
Rinnakkaistallennettu versio: acceptedVersion


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