Deep mutation modelling in cancer driver mutation and cancer driver gene detection

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dc.contributor Helsingin yliopisto, Matemaattis-luonnontieteellinen tiedekunta fi
dc.contributor University of Helsinki, Faculty of Science en
dc.contributor Helsingfors universitet, Matematisk-naturvetenskapliga fakulteten sv
dc.contributor.author Maljanen, Katri
dc.date.issued 2021
dc.identifier.uri URN:NBN:fi:hulib-202106072531
dc.identifier.uri http://hdl.handle.net/10138/330695
dc.description.abstract Cancer is a leading cause of death worldwide. Unlike its name would suggest, cancer is not a single disease. It is a group of diseases that arises from the expansion of a somatic cell clone. This expansion is thought to be a result of mutations that confer a selective advantage to the cell clone. These mutations that are advantageous to cells that result in their proliferation and escape of normal cell constraints are called driver mutations. The genes that contain driver mutations are known as driver genes. Studying these mutations and genes is important for understanding how cancer forms and evolves. Various methods have been developed that can discover these mutations and genes. This thesis focuses on a method called Deep Mutation Modelling, a deep learning based approach to predicting the probability of mutations. Deep Mutation Modelling’s output probabilities offer the possibility of creating sample and cancer type specific probability scores for mutations that reflect the pathogenicity of the mutations. Most methods in the past have made scores that are the same for all cancer types. Deep Mutation Modelling offers the opportunity to make a more personalised score. The main objectives of this thesis were to examine the Deep Mutation Modelling output as it was unknown what kind of features it has, see how the output compares against other scoring methods and how the probabilities work in mutation hotspots. Lastly, could the probabilities be used in a common driver gene discovery method. Overall, the goal was to see if Deep Mutation Modelling works and if it is competitive with other known methods. The findings indicate that Deep Mutation Modelling works in predicting driver mutations, but that it does not have sufficient power to do this reliably and requires further improvements. en
dc.language.iso eng
dc.publisher Helsingin yliopisto fi
dc.publisher University of Helsinki en
dc.publisher Helsingfors universitet sv
dc.subject cancer
dc.subject driver mutations
dc.subject driver genes
dc.subject deep learning
dc.title Deep mutation modelling in cancer driver mutation and cancer driver gene detection en
dc.type.ontasot pro gradu -tutkielmat fi
dc.type.ontasot master's thesis en
dc.type.ontasot pro gradu-avhandlingar sv
dct.identifier.urn URN:NBN:fi:hulib-202106072531
dc.subject.specialization Algoritminen bioinformatiikka fi
dc.subject.specialization Algorithmic Bioinformatics en
dc.subject.specialization Algoritmisk bioinformatik sv
dc.subject.degreeprogram Life Science Informatics -maisteriohjelma fi
dc.subject.degreeprogram Master's Programme in Life Science Informatics en
dc.subject.degreeprogram Magisterprogrammet i Life Science Informatics sv

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