Preterm birth rate after bivalent HPV vaccination : Registry-based follow-up of a randomized clinical trial

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Kalliala , I , Eriksson , T , Aro , K , Hokkanen , M , Lehtinen , M , Gissler , M & Nieminen , P 2021 , ' Preterm birth rate after bivalent HPV vaccination : Registry-based follow-up of a randomized clinical trial ' , Preventive Medicine , vol. 146 , 106473 . https://doi.org/10.1016/j.ypmed.2021.106473

Title: Preterm birth rate after bivalent HPV vaccination : Registry-based follow-up of a randomized clinical trial
Author: Kalliala, Ilkka; Eriksson, Tiina; Aro, Karoliina; Hokkanen, Mari; Lehtinen, Matti; Gissler, Mika; Nieminen, Pekka
Contributor organization: Clinicum
Department of Obstetrics and Gynecology
HUS Gynecology and Obstetrics
University of Helsinki
Helsinki University Hospital Area
Date: 2021-05
Language: eng
Number of pages: 5
Belongs to series: Preventive Medicine
ISSN: 0091-7435
DOI: https://doi.org/10.1016/j.ypmed.2021.106473
URI: http://hdl.handle.net/10138/330706
Abstract: A registry-based follow-up of pregnancy data until the end of 2014 was conducted based on a community randomized trial to assess human papillomavirus (HPV) vaccination strategies and a reference cohort from the same community with no intervention. Our objective was to determine whether prophylactic HPV vaccination (three doses of Cervarix? (AS04-HPV-16/18)-vaccine) affects preterm birth (PTB) rates. All identified 80,272 residents in 1992?95 birth cohorts in Finland were eligible for the trial and 20,513 of 39,420 (51.9%) females consented to participate. The final study population consisted of age-aligned 6226 HPV16/18 vaccinated females and 1770 HBV vaccinated (Engerix? B, hepatitis B-virus vaccine) females that did not receive HPV vaccine at the age of 18 from the 1992?93 birth cohorts, and 19,849 females from the 1990?91 non-vaccinated reference birth cohorts. We compared the rates of preterm (22 + 0?36 + 6 pregnancy weeks) and early preterm (22 + 0?31 + 6) per term (at least 37 + 0) singleton births among the HPVand non-HPV-vaccinated women, using nationwide Medical Birth Registry data. We observed 409 singleton first pregnancies lasting at least 22 + 0 weeks among 6226 HPV-vaccinated and 1923 among 21,619 non-HPV-vaccinated women. In the first pregnancy the PTB rate was 13/409 (3.2%) among the HPV-vaccinated and 98/1923 (5.1%) among the non-HPV-vaccinated (OR 0.61, 95% CI 0.34?1.09). Early preterm birth rate was 0/409 (0%) in the HPV-vaccinated women and 20/1923 (1.0%) in the non-HPV-vaccinated women (p = 0.04). PTB rate, especially early PTB rate, was lower among the HPVvaccinated women. Reduction of PTB incidence after prophylactic HPV vaccination would lead to public health benefits globally. Trial Registration:NCT00534638
Subject: Preterm birth
Human papillomavirus
HPV
Vaccine
3142 Public health care science, environmental and occupational health
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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