Increased mortality after post-stroke epilepsy following primary intracerebral hemorrhage

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Pysyväisosoite

http://hdl.handle.net/10138/330776

Lähdeviite

Lahti , A-M , Huhtakangas , J , Juvela , S , Bode , M K & Tetri , S 2021 , ' Increased mortality after post-stroke epilepsy following primary intracerebral hemorrhage ' , Epilepsy Research , vol. 172 , 106586 . https://doi.org/10.1016/j.eplepsyres.2021.106586

Julkaisun nimi: Increased mortality after post-stroke epilepsy following primary intracerebral hemorrhage
Tekijä: Lahti, Anna-Maija; Huhtakangas, Juha; Juvela, Seppo; Bode, Michaela K.; Tetri, Sami
Tekijän organisaatio: Clinicum
Department of Neurosciences
HUS Neurocenter
Neurokirurgian yksikkö
Päiväys: 2021-05
Kieli: eng
Sivumäärä: 6
Kuuluu julkaisusarjaan: Epilepsy Research
ISSN: 0920-1211
DOI-tunniste: https://doi.org/10.1016/j.eplepsyres.2021.106586
URI: http://hdl.handle.net/10138/330776
Tiivistelmä: Objectives: This study aimed to determine whether post-stroke epilepsy (PSE) predicts mortality, and to describe the most prominent causes of death (COD) in a long-term follow-up after primary intracerebral hemorrhage (ICH). Methods: We followed 3-month survivors of a population-based cohort of primary ICH patients in Northern Ostrobothnia, Finland, for a median of 8.8 years. Mortality and CODs were compared between those who developed PSE and those who did not. PSE was defined according to the ILAE guidelines. CODs were extracted from death certificates (Statistics Finland). Results: Of 961 patients, 611 survived for 3 months. 409 (66.9%) had died by the end of the follow-up. Pneumonia was the only COD that was significantly more common among the patients with PSE (56% vs. 37% of deaths). In the multivariable models, PSE (hazard ratio [HR] 1.41, 95% confidence interval [CI] 1.06 & ndash;1.87), age (HR 1.07, 95% CI 1.06 & ndash;1.08), male sex (HR 1.35, 95% CI 1.09 & ndash;1.67), dependency at 3 months (HR 1.52, 95% CI 1.24 & ndash;1.88), non-subcortical ICH location (subcortical location HR 0.78, 95% CI 0.61-0.99), diabetes (HR 1.43, 95% CI 1.07 & ndash;1.90) and cancer (HR 1.45, 95% CI 1.06 & ndash;1.98) predicted death in the long-term follow-up. Conclusion: PSE independently predicted higher late morality of ICH in our cohort. Pneumonia-related deaths were more common among the patients with PSE.
Avainsanat: Intracerebral hemorrhage
Post-Stroke epilepsy
Symptomatic epilepsy
Epilepsy
Mortality
Outcome
Long-Term
Epidemiology
INTERNATIONAL-LEAGUE
LATE SEIZURES
RISK-FACTOR
PREDICTORS
STROKE
DEATH
ILAE
3112 Neurosciences
3124 Neurology and psychiatry
Vertaisarvioitu: Kyllä
Tekijänoikeustiedot: cc_by
Pääsyrajoitteet: openAccess
Rinnakkaistallennettu versio: publishedVersion


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