Increased mortality after post-stroke epilepsy following primary intracerebral hemorrhage

Show simple item record Lahti, Anna-Maija Huhtakangas, Juha Juvela, Seppo Bode, Michaela K. Tetri, Sami 2021-06-09T10:03:01Z 2021-06-09T10:03:01Z 2021-05
dc.identifier.citation Lahti , A-M , Huhtakangas , J , Juvela , S , Bode , M K & Tetri , S 2021 , ' Increased mortality after post-stroke epilepsy following primary intracerebral hemorrhage ' , Epilepsy Research , vol. 172 , 106586 .
dc.identifier.other PURE: 164834661
dc.identifier.other PURE UUID: 52fe65c7-acf6-420f-9b6b-feba77f443e9
dc.identifier.other WOS: 000640490500001
dc.identifier.other ORCID: /0000-0003-4944-4983/work/104949652
dc.description.abstract Objectives: This study aimed to determine whether post-stroke epilepsy (PSE) predicts mortality, and to describe the most prominent causes of death (COD) in a long-term follow-up after primary intracerebral hemorrhage (ICH). Methods: We followed 3-month survivors of a population-based cohort of primary ICH patients in Northern Ostrobothnia, Finland, for a median of 8.8 years. Mortality and CODs were compared between those who developed PSE and those who did not. PSE was defined according to the ILAE guidelines. CODs were extracted from death certificates (Statistics Finland). Results: Of 961 patients, 611 survived for 3 months. 409 (66.9%) had died by the end of the follow-up. Pneumonia was the only COD that was significantly more common among the patients with PSE (56% vs. 37% of deaths). In the multivariable models, PSE (hazard ratio [HR] 1.41, 95% confidence interval [CI] 1.06 & ndash;1.87), age (HR 1.07, 95% CI 1.06 & ndash;1.08), male sex (HR 1.35, 95% CI 1.09 & ndash;1.67), dependency at 3 months (HR 1.52, 95% CI 1.24 & ndash;1.88), non-subcortical ICH location (subcortical location HR 0.78, 95% CI 0.61-0.99), diabetes (HR 1.43, 95% CI 1.07 & ndash;1.90) and cancer (HR 1.45, 95% CI 1.06 & ndash;1.98) predicted death in the long-term follow-up. Conclusion: PSE independently predicted higher late morality of ICH in our cohort. Pneumonia-related deaths were more common among the patients with PSE. en
dc.format.extent 6
dc.language.iso eng
dc.relation.ispartof Epilepsy Research
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Intracerebral hemorrhage
dc.subject Post-Stroke epilepsy
dc.subject Symptomatic epilepsy
dc.subject Epilepsy
dc.subject Mortality
dc.subject Outcome
dc.subject Long-Term
dc.subject Epidemiology
dc.subject LATE SEIZURES
dc.subject RISK-FACTOR
dc.subject PREDICTORS
dc.subject STROKE
dc.subject DEATH
dc.subject ILAE
dc.subject 3112 Neurosciences
dc.subject 3124 Neurology and psychiatry
dc.title Increased mortality after post-stroke epilepsy following primary intracerebral hemorrhage en
dc.type Article
dc.contributor.organization Clinicum
dc.contributor.organization Department of Neurosciences
dc.contributor.organization HUS Neurocenter
dc.contributor.organization Neurokirurgian yksikkö
dc.description.reviewstatus Peer reviewed
dc.relation.issn 0920-1211
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S0920121121000395_main.pdf 742.2Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record