Maternal Vitamin C and Iron Intake during Pregnancy and the Risk of Islet Autoimmunity and Type 1 Diabetes in Children : A Birth Cohort Study

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Mattila , M , Hakola , L , Niinisto , S , Tapanainen , H , Takkinen , H-M , Ahonen , S , Ilonen , J , Toppari , J , Veijola , R , Knip , M & Virtanen , S M 2021 , ' Maternal Vitamin C and Iron Intake during Pregnancy and the Risk of Islet Autoimmunity and Type 1 Diabetes in Children : A Birth Cohort Study ' , Nutrients , vol. 13 , no. 3 , 928 . https://doi.org/10.3390/nu13030928

Title: Maternal Vitamin C and Iron Intake during Pregnancy and the Risk of Islet Autoimmunity and Type 1 Diabetes in Children : A Birth Cohort Study
Author: Mattila, Markus; Hakola, Leena; Niinisto, Sari; Tapanainen, Heli; Takkinen, Hanna-Mari; Ahonen, Suvi; Ilonen, Jorma; Toppari, Jorma; Veijola, Riitta; Knip, Mikael; Virtanen, Suvi M.
Contributor organization: HUS Children and Adolescents
Children's Hospital
Research Programs Unit
Helsinki University Hospital Area
CAMM - Research Program for Clinical and Molecular Metabolism
Date: 2021-03
Language: eng
Number of pages: 11
Belongs to series: Nutrients
ISSN: 2072-6643
DOI: https://doi.org/10.3390/nu13030928
URI: http://hdl.handle.net/10138/330808
Abstract: Our aim was to study the associations between maternal vitamin C and iron intake during pregnancy and the offspring's risk of developing islet autoimmunity and type 1 diabetes. The study was a part of the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) prospective birth cohort including children genetically at risk of type 1 diabetes born between 1997-2004. The diets of 4879 mothers in late pregnancy were assessed with a validated food frequency questionnaire. The outcomes were islet autoimmunity and type 1 diabetes. Cox proportional hazards regression analysis adjusted for energy, family history of diabetes, human leukocyte antigen (HLA) genotype and sex was used for statistical analyses. Total intake of vitamin C or iron from food and supplements was not associated with the risk of islet autoimmunity (vitamin C: HR 0.91: 95% CI (0.80, 1.03), iron: 0.98 (0.87, 1.10)) or type 1 diabetes (vitamin C: 1.01 (0.87, 1.17), iron: 0.92 (0.78, 1.08)), neither was the use of vitamin C or iron supplements associated with the outcomes. In conclusion, no association was found between maternal vitamin C or iron intake during pregnancy and the risk of islet autoimmunity or type 1 diabetes in the offspring.
Subject: pregnancy
nutrition
vitamin C
ascorbic acid
iron
islet autoimmunity
type 1 diabetes
birth cohort
3123 Gynaecology and paediatrics
3143 Nutrition
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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