Timing of pacemaker and ICD implantation in LMNA mutation carriers

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Ollila , L H , Nikus , K , Parikka , H , Weckström , S & Heliö , T 2021 , ' Timing of pacemaker and ICD implantation in LMNA mutation carriers ' , Open Heart , vol. 8 , no. 1 , 001622 . https://doi.org/10.1136/openhrt-2021-001622

Title: Timing of pacemaker and ICD implantation in LMNA mutation carriers
Author: Ollila, Laura Helena; Nikus, Kjell; Parikka, Hannu; Weckström, Sini; Heliö, Tiina
Contributor organization: HUS Heart and Lung Center
Department of Medicine
Date: 2021
Language: eng
Number of pages: 7
Belongs to series: Open Heart
ISSN: 2053-3624
DOI: https://doi.org/10.1136/openhrt-2021-001622
URI: http://hdl.handle.net/10138/330935
Abstract: Aims LMNA-cardiomyopathy is often associated with pathology in the cardiac conduction system necessitating device implantations. The aim was to study the timing and types of device implantations and need for re-implantations in LMNA mutation carriers. Methods We studied the hospital records of 60 LMNA mutation carriers concerning device implantations and re-implantations and their indications. Data were collected until April 2019. Results The median follow-up time from the first ECG recording to the last clinical follow-up, transplantation, or death was 7.7 (IQR=9.1) years. Altogether 61.7% (n=37) of the LMNA mutation carriers received a pacemaker or an implantable cardioverter defibrillator (ICD), and of them 27.0% (n=10) needed a device upgrade. Notably, in some patients the upgrade took place very soon after the first implantation. The first device was implanted at an average age of 47.9 years (SD=9.5), whereas the upgrade took place at an average age of 50.3 years (SD=8.1). Most upgrades were ICD implantations. Male patients underwent device upgrade more often and at a younger age than women. By the end of follow-up, 35.0% (n=21) of the patients fulfilled echocardiographic criteria for dilated cardiomyopathy, and 90.5% of them (n=19) needed pacemaker implantation. Conclusion Most LMNA mutation carriers underwent pacemaker implantation in this study. Due to the progressive nature of LMNA-cardiomyopathy, device upgrades are quite common. An ICD should be considered when the initial device implantation is planned in an LMNA mutation carrier.
Subject: arrhythmias
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by_nc
Usage restriction: openAccess
Self-archived version: publishedVersion

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