Modified Atkins diet modifies cardiopulmonary exercise characteristics and promotes hyperventilation in healthy subjects

Show full item record



Permalink

http://hdl.handle.net/10138/331183

Citation

Ratia , N , Pietiläinen , K H , Auranen , M , Saksa , L , Luukkonen , R , Suomalainen , A & Piirilä , P 2021 , ' Modified Atkins diet modifies cardiopulmonary exercise characteristics and promotes hyperventilation in healthy subjects ' , Journal of functional foods , vol. 81 , 104459 . https://doi.org/10.1016/j.jff.2021.104459

Title: Modified Atkins diet modifies cardiopulmonary exercise characteristics and promotes hyperventilation in healthy subjects
Author: Ratia, Nadja; Pietiläinen, Kirsi H.; Auranen, Mari; Saksa, Lauri; Luukkonen, Ritva; Suomalainen, Anu; Piirilä, Päivi
Contributor organization: University of Helsinki
HUS Medical Imaging Center
Department of Diagnostics and Therapeutics
Helsinki University Hospital Area
HUS Abdominal Center
Department of Medicine
Clinicum
Research Programs Unit
CAMM - Research Program for Clinical and Molecular Metabolism
Faculty of Medicine
HUS Neurocenter
Staff Services
Neurologian yksikkö
HUSLAB
STEMM - Stem Cells and Metabolism Research Program
Department of Neurosciences
Anu Wartiovaara / Principal Investigator
Neuroscience Center
Helsinki Institute of Life Science HiLIFE
Date: 2021-06
Language: eng
Number of pages: 7
Belongs to series: Journal of functional foods
ISSN: 1756-4646
DOI: https://doi.org/10.1016/j.jff.2021.104459
URI: http://hdl.handle.net/10138/331183
Abstract: Background: Low-carbohydrate diets, including the modified Atkins diet (mAD), are commonly used to promote weight loss, improve exercise performance, and treat refractory epilepsy and inherited metabolism disorders. However, the effects of the high-fat-low-carbohydrate diet on the physiology of healthy subjects still need further study. We evaluated the physiological influence of mAD on cardiopulmonary exercise results in healthy adult subjects. Materials and methods: Ten healthy volunteers followed mAD for four weeks with laboratory follow-up. Cardiopulmonary exercise tests were performed before, and at the end of mAD, and venous lactate, ammonia, and blood gases were collected before, during, and after exercise testing. Results and conclusions: Four-week mAD decreased the subjects' mechanical efficiency in the cardiopulmonary exercise test and caused increased ventilation and decreased fraction of expired CO2 in maximal exercise. This evidence suggests that mAD can cause hyperventilation tendency at least in the short term, a possible adverse effect of the diet.
Subject: Low-carbohydrate diet
Cardiopulmonary exercise testing
Lactate
Hyperventilation
The fraction of expired CO2
Modified Atkins' diet
LOW-CARBOHYDRATE-DIET
WEIGHT-LOSS
FAT DIET
RANDOMIZED-TRIAL
MAXIMAL EXERCISE
KETOGENIC DIET
PERFORMANCE
METABOLISM
LACTATE
RESPONSES
3143 Nutrition
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion


Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S1756464621001080_main.pdf 997.6Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record