Modified Atkins diet modifies cardiopulmonary exercise characteristics and promotes hyperventilation in healthy subjects

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Ratia , N , Pietiläinen , K H , Auranen , M , Saksa , L , Luukkonen , R , Suomalainen , A & Piirilä , P 2021 , ' Modified Atkins diet modifies cardiopulmonary exercise characteristics and promotes hyperventilation in healthy subjects ' , Journal of functional foods , vol. 81 , 104459 . https://doi.org/10.1016/j.jff.2021.104459

Title: Modified Atkins diet modifies cardiopulmonary exercise characteristics and promotes hyperventilation in healthy subjects
Author: Ratia, Nadja; Pietiläinen, Kirsi H.; Auranen, Mari; Saksa, Lauri; Luukkonen, Ritva; Suomalainen, Anu; Piirilä, Päivi
Contributor: University of Helsinki, University of Helsinki
University of Helsinki, HUS Abdominal Center
University of Helsinki, HUS Neurocenter
University of Helsinki, HUSLAB
University of Helsinki, HUS Medical Imaging Center
Date: 2021-06
Language: eng
Number of pages: 7
Belongs to series: Journal of functional foods
ISSN: 1756-4646
URI: http://hdl.handle.net/10138/331183
Abstract: Background: Low-carbohydrate diets, including the modified Atkins diet (mAD), are commonly used to promote weight loss, improve exercise performance, and treat refractory epilepsy and inherited metabolism disorders. However, the effects of the high-fat-low-carbohydrate diet on the physiology of healthy subjects still need further study. We evaluated the physiological influence of mAD on cardiopulmonary exercise results in healthy adult subjects. Materials and methods: Ten healthy volunteers followed mAD for four weeks with laboratory follow-up. Cardiopulmonary exercise tests were performed before, and at the end of mAD, and venous lactate, ammonia, and blood gases were collected before, during, and after exercise testing. Results and conclusions: Four-week mAD decreased the subjects' mechanical efficiency in the cardiopulmonary exercise test and caused increased ventilation and decreased fraction of expired CO2 in maximal exercise. This evidence suggests that mAD can cause hyperventilation tendency at least in the short term, a possible adverse effect of the diet.
Subject: Low-carbohydrate diet
Cardiopulmonary exercise testing
Lactate
Hyperventilation
The fraction of expired CO2
Modified Atkins' diet
LOW-CARBOHYDRATE-DIET
WEIGHT-LOSS
FAT DIET
RANDOMIZED-TRIAL
MAXIMAL EXERCISE
KETOGENIC DIET
PERFORMANCE
METABOLISM
LACTATE
RESPONSES
3143 Nutrition
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