Matrix metalloproteinase-2,-7, and-9 activities in dogs with idiopathic pulmonary fibrosis compared to healthy dogs and dogs with other respiratory diseases

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dc.contributor.author Määttä, Merita
dc.contributor.author Laurila, Henna P.
dc.contributor.author Holopainen, Saila
dc.contributor.author Aaltonen, Kaisa
dc.contributor.author Lilja-Maula, Liisa
dc.contributor.author Viitanen, Sanna
dc.contributor.author Rajamaki, Minna M.
dc.date.accessioned 2021-06-16T07:53:01Z
dc.date.available 2021-06-16T07:53:01Z
dc.date.issued 2021
dc.identifier.citation Määttä , M , Laurila , H P , Holopainen , S , Aaltonen , K , Lilja-Maula , L , Viitanen , S & Rajamaki , M M 2021 , ' Matrix metalloproteinase-2,-7, and-9 activities in dogs with idiopathic pulmonary fibrosis compared to healthy dogs and dogs with other respiratory diseases ' , Journal of Veterinary Internal Medicine , vol. 35 , no. 1 , pp. 462-471 . https://doi.org/10.1111/jvim.15970
dc.identifier.other PURE: 158682749
dc.identifier.other PURE UUID: 52a46891-53c0-4855-b899-99d3a46cae29
dc.identifier.other WOS: 000596046600001
dc.identifier.other ORCID: /0000-0001-7198-1529/work/99108971
dc.identifier.uri http://hdl.handle.net/10138/331343
dc.description.abstract Background Canine idiopathic pulmonary fibrosis (CIPF) is a chronic, interstitial lung disease that mainly affects West Highland white terriers (WHWTs) and is characterized by excessive deposition of extracellular matrix (ECM) in the lung. Matrix metalloproteinases (MMPs) participate in remodeling of ECM. Objectives To compare metalloproteinase-2, -7 and -9 activities in blood or bronchoalveolar lavage fluid (BALF) samples or both of CIPF WHWTs with healthy WHWTs, healthy dogs of other breeds, and dogs with other lung diseases and determine if these MMPs could be used as diagnostic and prognostic markers for CIPF. Animals Forty-four CIPF WHWTs, 24 dogs with chronic bronchitis (CB), 17 with eosinophilic bronchopneumopathy (EBP), 10 with bacterial pneumonia, 39 healthy WHWTs, and 35 healthy dogs of other breeds. Methods Cross-sectional observational study. Pro-MMP and active MMP activities were analyzed by zymography. Results In serum, significantly higher (P <.01) pro-MMP-7 activities were observed in CIPF WHWTs compared to healthy dogs of other breeds, dogs with CB and dogs with EBP. In BALF of CIPF WHWTs, both pro-MMP-9 and pro-MMP-2 activities were significantly higher (P <.01) compared to healthy WHWTs, but these differences were not detected in plasma. The CIPF WHWTs had significantly higher (P <.05) activities of pro-MMP-9 compared to dogs with CB and of pro-MMP-2 compared to dogs with CB and EBP. No statistically significant prognostic factors were observed in CIPF WHWTs. Conclusions and clinical relevance Serum MMP-7 and BALF MMP-2 and -9 potentially may be useful diagnostic markers but not prognostic markers for CIPF. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof Journal of Veterinary Internal Medicine
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject canine
dc.subject gelatinases
dc.subject lung
dc.subject matrilysin
dc.subject HIGHLAND WHITE TERRIERS
dc.subject GENE-EXPRESSION
dc.subject MMP-7
dc.subject BETA
dc.subject MATRIX-METALLOPROTEINASE-9
dc.subject PATHOGENESIS
dc.subject MATRILYSIN
dc.subject PROGNOSIS
dc.subject MORTALITY
dc.subject APOPTOSIS
dc.subject 413 Veterinary science
dc.title Matrix metalloproteinase-2,-7, and-9 activities in dogs with idiopathic pulmonary fibrosis compared to healthy dogs and dogs with other respiratory diseases en
dc.type Article
dc.contributor.organization Equine and Small Animal Medicine
dc.contributor.organization Helsinki One Health (HOH)
dc.contributor.organization Departments of Faculty of Veterinary Medicine
dc.contributor.organization Hannes Tapani Lohi / Principal Investigator
dc.contributor.organization Small Animal Hospital
dc.contributor.organization Minna Marjaana Rajamäki / Principal Investigator
dc.contributor.organization University Management
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1111/jvim.15970
dc.relation.issn 0891-6640
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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