Radiation-induced accelerated aging of the brain vasculature in young adult survivors of childhood brain tumors

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dc.contributor.author Remes, Tiina Maria
dc.contributor.author Suo-Palosaari, Maria Helena
dc.contributor.author Koskenkorva, Päivi K. T.
dc.contributor.author Sutela, Anna K.
dc.contributor.author Toiviainen-Salo, Sanna-Maria
dc.contributor.author Arikoski, Pekka M.
dc.contributor.author Arola, Mikko O.
dc.contributor.author Heikkilä, Vesa-Pekka
dc.contributor.author Kapanen, Mika
dc.contributor.author Lähteenmäki, Päivi Maria
dc.contributor.author Lönnqvist, Tuula R. I.
dc.contributor.author Niiniviita, Hannele
dc.contributor.author Pokka, Tytti M-L
dc.contributor.author Porra, Liisa
dc.contributor.author Riikonen, V. Pekka
dc.contributor.author Seppälä, Jan
dc.contributor.author Sirkiä, Kirsti H.
dc.contributor.author Vanhanen, Antti
dc.contributor.author Rantala, Heikki M. J.
dc.contributor.author Harila-Saari, Arja H.
dc.contributor.author Ojaniemi, Marja K.
dc.date.accessioned 2021-06-17T11:45:01Z
dc.date.available 2021-06-17T11:45:01Z
dc.date.issued 2020-08
dc.identifier.citation Remes , T M , Suo-Palosaari , M H , Koskenkorva , P K T , Sutela , A K , Toiviainen-Salo , S-M , Arikoski , P M , Arola , M O , Heikkilä , V-P , Kapanen , M , Lähteenmäki , P M , Lönnqvist , T R I , Niiniviita , H , Pokka , T M-L , Porra , L , Riikonen , V P , Seppälä , J , Sirkiä , K H , Vanhanen , A , Rantala , H M J , Harila-Saari , A H & Ojaniemi , M K 2020 , ' Radiation-induced accelerated aging of the brain vasculature in young adult survivors of childhood brain tumors ' , Neuro-Oncology practice , vol. 7 , no. 4 , pp. 415-427 . https://doi.org/10.1093/nop/npaa002
dc.identifier.other PURE: 158762344
dc.identifier.other PURE UUID: 6c128001-d8a5-49b7-b2cf-d498ac1cbb38
dc.identifier.other WOS: 000593119700009
dc.identifier.other ORCID: /0000-0003-3639-944X/work/86483404
dc.identifier.uri http://hdl.handle.net/10138/331486
dc.description.abstract Background. Cranial radiotherapy may damage the cerebral vasculature. The aim of this study was to understand the prevalence and risk factors of cerebrovascular disease (CVD) and white matter hyperintensities (WMHs) in childhood brain tumors (CBT) survivors treated with radiotherapy. Methods. Seventy CBT survivors who received radiotherapy were enrolled in a cross-sectional study at a median 20 years after radiotherapy cessation. The prevalence of and risk factors for CVD were investigated using MRI, MRA, and laboratory testing. Tumors, their treatment, and stroke-related data were retrieved from patients' files. Results. Forty-four individuals (63%) had CVD at a median age of 27 years (range, 16-43 years). The prevalence rates at 20 years for CVD, small-vessel disease, and large-vessel disease were 52%, 38%, and 16%, respectively. Ischemic infarcts were diagnosed in 6 survivors, and cerebral hemorrhage in 2. Lacunar infarcts were present in 7, periventricular or deep WMHs in 34 (49%), and mineralizing microangiopathy in 21 (30%) survivors. Multiple pathologies were detected in 44% of the participants, and most lesions were located in a high-dose radiation area. Higher blood pressure was associated with CVD and a presence of WMHs. Higher cholesterol levels increased the risk of ischemic infarcts and WMHs, and lower levels of high-density lipoprotein and higher waist circumference increased the risk of lacunar infarcts. Conclusions. Treating CBTs with radiotherapy increases the risk of early CVD and WMHs in young adult survivors. These results suggest an urgent need for investigating CVD prevention in CBT patients. en
dc.format.extent 13
dc.language.iso eng
dc.relation.ispartof Neuro-Oncology practice
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject brain tumor
dc.subject cerebrovascular disease
dc.subject radiotherapy
dc.subject stroke
dc.subject survivor
dc.subject CEREBRAL WHITE-MATTER
dc.subject SMALL-VESSEL DISEASE
dc.subject HEALTH-CARE PROFESSIONALS
dc.subject RISK-FACTORS
dc.subject ISCHEMIC-STROKE
dc.subject CHOLESTEROL LEVELS
dc.subject BLOOD-PRESSURE
dc.subject RADIOTHERAPY
dc.subject MICROBLEEDS
dc.subject ASSOCIATION
dc.subject 3112 Neurosciences
dc.subject 3124 Neurology and psychiatry
dc.subject 3122 Cancers
dc.title Radiation-induced accelerated aging of the brain vasculature in young adult survivors of childhood brain tumors en
dc.type Article
dc.contributor.organization HUS Medical Imaging Center
dc.contributor.organization Department of Diagnostics and Therapeutics
dc.contributor.organization University of Helsinki
dc.contributor.organization Helsinki University Hospital Area
dc.contributor.organization HUS Children and Adolescents
dc.contributor.organization Clinicum
dc.contributor.organization Lastentautien yksikkö
dc.contributor.organization Children's Hospital
dc.contributor.organization Department of Physics
dc.contributor.organization HUS Comprehensive Cancer Center
dc.contributor.organization Department of Oncology
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1093/nop/npaa002
dc.relation.issn 2054-2577
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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