Associations Between IFI44L Gene Variants and Rates of Respiratory Tract Infections During Early Childhood

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Lempainen , J , Korhonen , L S , Kantojärvi , K , Heinonen , S , Toivonen , L , Räty , P , Ramilo , O , Mejias , A , Vuorinen , T , Waris , M , Karlsson , L , Karlsson , H , Laine , A-P , Paunio , T & Peltola , V 2021 , ' Associations Between IFI44L Gene Variants and Rates of Respiratory Tract Infections During Early Childhood ' , Journal of Infectious Diseases , vol. 223 , no. 1 , pp. 157-165 . https://doi.org/10.1093/infdis/jiaa341 , https://doi.org/10.1093/infdis/jiaa341

Title: Associations Between IFI44L Gene Variants and Rates of Respiratory Tract Infections During Early Childhood
Author: Lempainen, Johanna; Korhonen, Laura S.; Kantojärvi, Katri; Heinonen, Santtu; Toivonen, Laura; Räty, Panu; Ramilo, Octavio; Mejias, Asuncion; Vuorinen, Tytti; Waris, Matti; Karlsson, Linnea; Karlsson, Hasse; Laine, Antti-Pekka; Paunio, Tiina; Peltola, Ville
Contributor organization: HUS Children and Adolescents
Department of Psychiatry
SLEEPWELL Research Program
Faculty of Medicine
University of Helsinki
Helsinki University Hospital Area
Clinicum
Children's Hospital
HUS Psychiatry
Date: 2021-01-01
Language: eng
Number of pages: 9
Belongs to series: Journal of Infectious Diseases
ISSN: 0022-1899
DOI: https://doi.org/10.1093/infdis/jiaa341
URI: http://hdl.handle.net/10138/331643
Abstract: Background. Genetic heterogeneity in type I interferon (IFN)-related gene IFI44L may account for variable susceptibility to respiratory tract infections (RTIs) in children. Methods. In 2 prospective, population-based birth cohorts, the STEPS Study and the FinnBrain Birth Cohort Study, IFI44L genotypes for rs273259 and rs1333969 were determined in relation to the development of RTIs until 1 or 2 years of age, respectively. At age 3 months, whole-blood transcriptional profiles were analyzed and nasal samples were tested for respiratory viruses in a subset of children. Results. In the STEPS Study (n=1135), IFI44L minor/minor gene variants were associated with lower rates of acute otitis media episodes (adjusted incidence rate ratio, 0.77 [95% confidence interval, .61-.96] for rs273259 and 0.74 [.55-.99] for rs1333969) and courses of antibiotics for RTIs (0.76 [.62-.95] and 0.73 [.56-.97], respectively. In the FinnBrain cohort (n=971), IFI44L variants were associated with lower rates of RTIs and courses of antibiotics for RTIs. In respiratory virus-positive 3-month-old children, IFI44L gene variants were associated with decreased expression levels of IFI44L and several other IFN-related genes. Conclusions. Variant forms of IFI44L gene were protective against early-childhood RTIs or acute otitis media, and they attenuated IFN pathway activation by respiratory viruses.
Subject: 3111 Biomedicine
acute otitis media
interferon pathway
polymorphisms
respiratory tract infections
transcriptome
COHORT PROFILE
OTITIS-MEDIA
POLYMORPHISMS
CHILDREN
COMPLICATION
SYMPTOMS
TOOL
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: acceptedVersion


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