Phage-based target discovery and its exploitation towards novel antibacterial molecules

Show full item record



Permalink

http://hdl.handle.net/10138/331651

Citation

Wan , X , Hendrix , H , Skurnik , M & Lavigne , R 2021 , ' Phage-based target discovery and its exploitation towards novel antibacterial molecules ' , Current Opinion in Biotechnology , vol. 68 , pp. 1-7 . https://doi.org/10.1016/j.copbio.2020.08.015

Title: Phage-based target discovery and its exploitation towards novel antibacterial molecules
Author: Wan, Xing; Hendrix, Hanne; Skurnik, Mikael; Lavigne, Rob
Contributor organization: Department of Microbiology
Medicum
Research Programs Unit
HUMI - Human Microbiome Research
Department of Bacteriology and Immunology
Helsinki One Health (HOH)
HUSLAB
Mikael Skurnik / Principal Investigator
Date: 2021-04
Language: eng
Number of pages: 7
Belongs to series: Current Opinion in Biotechnology
ISSN: 0958-1669
DOI: https://doi.org/10.1016/j.copbio.2020.08.015
URI: http://hdl.handle.net/10138/331651
Abstract: The deeply intertwined evolutionary history between bacteriophages and bacteria has endowed phages with highly specific mechanisms to hijack bacterial cell metabolism for their propagation. Here, we present a comprehensive, phage-driven strategy to reveal novel antibacterial targets by the exploitation of phage-bacteria interactions. This strategy will enable the design of small molecules, which mimic the inhibitory phage proteins, and allow the subsequent hit-to-lead development of these antimicrobial compounds. This proposed small molecule approach is distinct from phage therapy and phage enzyme-based antimicrobials and may produce a more sustainable generation of new antibiotics that exploit novel bacterial targets and act in a pathogen-specific manner.
Subject: COLI RNA-POLYMERASE
DRUG DISCOVERY
TRANSCRIPTION
INHIBITION
PROTEINS
1182 Biochemistry, cell and molecular biology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S0958166920301221_main.pdf 460.7Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record