Indocyanine Green-Assisted and LED-Light-Activated Antibacterial Photodynamic Therapy Reduces Dental Plaque

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http://hdl.handle.net/10138/331664

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Nikinmaa , S , Moilanen , N , Sorsa , T , Rantala , J , Alapulli , H , Kotiranta , A , Auvinen , P , Kankuri , E , Meurman , J H & Pätilä , T 2021 , ' Indocyanine Green-Assisted and LED-Light-Activated Antibacterial Photodynamic Therapy Reduces Dental Plaque ' , Dentistry Journal , vol. 9 , no. 5 , 52 . https://doi.org/10.3390/dj9050052

Title: Indocyanine Green-Assisted and LED-Light-Activated Antibacterial Photodynamic Therapy Reduces Dental Plaque
Author: Nikinmaa, Sakari; Moilanen, Niina; Sorsa, Timo; Rantala, Juha; Alapulli, Heikki; Kotiranta, Anja; Auvinen, Petri; Kankuri, Esko; Meurman, Jukka H.; Pätilä, Tommi
Other contributor: University of Helsinki, Department of Oral and Maxillofacial Diseases
University of Helsinki, Suu- ja leukakirurgian yksikkö
University of Helsinki, Faculty of Medicine
University of Helsinki, HUS Head and Neck Center
University of Helsinki, Institute of Biotechnology
University of Helsinki, Esko Markus Kankuri / Principal Investigator
University of Helsinki, Clinicum
University of Helsinki, HUS Heart and Lung Center












Date: 2021-05
Language: eng
Number of pages: 11
Belongs to series: Dentistry Journal
ISSN: 2304-6767
DOI: https://doi.org/10.3390/dj9050052
URI: http://hdl.handle.net/10138/331664
Abstract: Aim: This study aimed to determine the feasibility and first efficacy of indocyanine green (ICG)-assisted antimicrobial photodynamictherapy (aPDT) as activated using LED light to the dental plaque. Methods: Fifteen healthy adults were assigned to this four-day randomized study. After rinsing with ICG, 100 J/cm(2) of 810 nm LED light was applied to the aPDT-treatment area. Plaque area and gingival crevicular fluid (GCF) matrix metalloproteinase-8 (MMP-8) were measured, and plaque bacteriomes before and after the study were analyzed using 16S rRNA sequencing. Results: aPDT administration was preformed successfully and plaque-specifically with the combination of ICG and the applicator. Total plaque area and endpoint MMP-8 levels were reduced on the aPDT-treatment side. aPDT reduced Streptococcus, Acinetobacteria, Capnocytophaga, and Rothia bacteria species in plaques. Conclusion: ICG-assisted aPDT reduces plaque forming bacteria and exerts anti-inflammatory and anti-proteolytic effects.
Subject: antibacterial photodynamic therapy
dental plaque
gingivitis
GINGIVAL CREVICULAR FLUID
NEAR-INFRARED LIGHT
CHRONIC PERIODONTITIS
ORAL-HEALTH
MICROBIOTA
DISEASES
SALIVA
CELLS
313 Dentistry
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