Association of sleep duration in middle and old age with incidence of dementia

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Sabia , S , Fayosse , A , Dumurgier , J , van Hees , V T , Paquet , C , Sommerlad , A , Kivimäki , M , Dugravot , A & Singh-Manoux , A 2021 , ' Association of sleep duration in middle and old age with incidence of dementia ' , Nature Communications , vol. 12 , no. 1 , 2289 . https://doi.org/10.1038/s41467-021-22354-2

Title: Association of sleep duration in middle and old age with incidence of dementia
Author: Sabia, Severine; Fayosse, Aurore; Dumurgier, Julien; van Hees, Vincent T.; Paquet, Claire; Sommerlad, Andrew; Kivimäki, Mika; Dugravot, Aline; Singh-Manoux, Archana
Contributor: University of Helsinki, Clinicum
Date: 2021-04-20
Language: eng
Number of pages: 10
Belongs to series: Nature Communications
ISSN: 2041-1723
URI: http://hdl.handle.net/10138/331676
Abstract: Sleep dysregulation is a feature of dementia but it remains unclear whether sleep duration prior to old age is associated with dementia incidence. Using data from 7959 participants of the Whitehall II study, we examined the association between sleep duration and incidence of dementia (521 diagnosed cases) using a 25-year follow-up. Here we report higher dementia risk associated with a sleep duration of six hours or less at age 50 and 60, compared with a normal (7h) sleep duration, although this was imprecisely estimated for sleep duration at age 70 (hazard ratios (HR) 1.22 (95% confidence interval 1.01-1.48), 1.37 (1.10-1.72), and 1.24 (0.98-1.57), respectively). Persistent short sleep duration at age 50, 60, and 70 compared to persistent normal sleep duration was also associated with a 30% increased dementia risk independently of sociodemographic, behavioural, cardiometabolic, and mental health factors. These findings suggest that short sleep duration in midlife is associated with an increased risk of late-onset dementia.
Subject: ALZHEIMERS-DISEASE
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3112 Neurosciences
3124 Neurology and psychiatry
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