Molecular pathways behind acquired obesity : Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI

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van der Kolk , B W , Saari , S , Lovric , A , Arif , M , Alvarez , M , Ko , A , Miao , Z , Sahebekhtiari , N , Muniandy , M , Heinonen , S , Oghabian , A , Jokinen , R , Jukarainen , S , Hakkarainen , A , Lundbom , J , Kuula , J , Groop , P-H , Tukiainen , T , Lundbom , N , Rissanen , A , Kaprio , J , Williams , E G , Zamboni , N , Mardinoglu , A , Pajukanta , P & Pietiläinen , K H 2021 , ' Molecular pathways behind acquired obesity : Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI ' , Cell Reports Medicine , vol. 2 , no. 4 , 100226 . https://doi.org/10.1016/j.xcrm.2021.100226

Title: Molecular pathways behind acquired obesity : Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI
Author: van der Kolk, Birgitta W.; Saari, Sina; Lovric, Alen; Arif, Muhammad; Alvarez, Marcus; Ko, Arthur; Miao, Zong; Sahebekhtiari, Navid; Muniandy, Maheswary; Heinonen, Sini; Oghabian, Ali; Jokinen, Riikka; Jukarainen, Sakari; Hakkarainen, Antti; Lundbom, Jesper; Kuula, Juho; Groop, Per-Henrik; Tukiainen, Taru; Lundbom, Nina; Rissanen, Aila; Kaprio, Jaakko; Williams, Evan G.; Zamboni, Nicola; Mardinoglu, Adil; Pajukanta, Paivi; Pietiläinen, Kirsi H.
Contributor: University of Helsinki, CAMM - Research Program for Clinical and Molecular Metabolism
University of Helsinki, CAMM - Research Program for Clinical and Molecular Metabolism
University of Helsinki, CAMM - Research Program for Clinical and Molecular Metabolism
University of Helsinki, CAMM - Research Program for Clinical and Molecular Metabolism
University of Helsinki, Diabetes and Obesity Research Program
University of Helsinki, CAMM - Research Program for Clinical and Molecular Metabolism
University of Helsinki, Research Programs Unit
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, HUS Medical Imaging Center
University of Helsinki, HUS Medical Imaging Center
University of Helsinki, HUS Diagnostic Center
University of Helsinki, HUS Abdominal Center
University of Helsinki, Genomics of Sex Differences
University of Helsinki, HUS Medical Imaging Center
University of Helsinki, HUS Internal Medicine and Rehabilitation
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, HUS Abdominal Center
Date: 2021-04-20
Language: eng
Number of pages: 17
Belongs to series: Cell Reports Medicine
ISSN: 2666-3791
URI: http://hdl.handle.net/10138/331702
Abstract: Tissue-specific mechanisms prompting obesity-related development complications in humans remain unclear. We apply multiomics analyses of subcutaneous adipose tissue and skeletal muscle to examine the effects of acquired obesity among 49 BMI-discordant monozygotic twin pairs. Overall, adipose tissue appears to be more affected by excess body weight than skeletal muscle. In heavier co-twins, we observe a transcriptional pattern of downregulated mitochondrial pathways in both tissues and upregulated inflammatory pathways in adipose tissue. In adipose tissue, heavier co-twins exhibit lower creatine levels; in skeletal muscle, glycolysis- and redox stress-related protein and metabolite levels remain higher. Furthermore, metabolomics analyses in both tissues reveal that several proinflammatory lipids are higher and six of the same lipid derivatives are lower in acquired obesity. Finally, in adipose tissue, but not in skeletal muscle, mitochondrial downregulation and upregulated inflammation are associated with a fatty liver, insulin resistance, and dyslipidemia, suggesting that adipose tissue dominates in acquired obesity.
Subject: INSULIN-RESISTANCE
GENE-EXPRESSION
PROTEOME
TRANSCRIPTOME
ACID
IDENTIFICATION
INFLAMMATION
SIGNATURES
ACCURATE
HEALTH
1182 Biochemistry, cell and molecular biology
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