RNA atlas of human bacterial pathogens uncovers stress dynamics linked to infection

Show full item record



Permalink

http://hdl.handle.net/10138/331748

Citation

Avican , K , Aldahdooh , J , Togninalli , M , Mahmud , A K M F , Tang , J , Borgwardt , K M , Rhen , M & Fällman , M 2021 , ' RNA atlas of human bacterial pathogens uncovers stress dynamics linked to infection ' , Nature Communications , vol. 12 , no. 1 , 3282 . https://doi.org/10.1038/s41467-021-23588-w

Title: RNA atlas of human bacterial pathogens uncovers stress dynamics linked to infection
Author: Avican, Kemal; Aldahdooh, Jehad; Togninalli, Matteo; Mahmud, A. K. M. Firoj; Tang, Jing; Borgwardt, Karsten M.; Rhen, Mikael; Fällman, Maria
Contributor organization: Research Program in Systems Oncology
Institute for Molecular Medicine Finland
Date: 2021-06-02
Language: eng
Number of pages: 14
Belongs to series: Nature Communications
ISSN: 2041-1723
DOI: https://doi.org/10.1038/s41467-021-23588-w
URI: http://hdl.handle.net/10138/331748
Abstract: Bacterial processes necessary for adaption to stressful host environments are potential targets for new antimicrobials. Here, we report large-scale transcriptomic analyses of 32 human bacterial pathogens grown under 11 stress conditions mimicking human host environments. The potential relevance of the in vitro stress conditions and responses is supported by comparisons with available in vivo transcriptomes of clinically important pathogens. Calculation of a probability score enables comparative cross-microbial analyses of the stress responses, revealing common and unique regulatory responses to different stresses, as well as overlapping processes participating in different stress responses. We identify conserved and species-specific 'universal stress responders', that is, genes showing altered expression in multiple stress conditions. Non-coding RNAs are involved in a substantial proportion of the responses. The data are collected in a freely available, interactive online resource (PATHOgenex). Bacterial stress responses are potential targets for new antimicrobials. Here, Avican et al. present global transcriptomes for 32 bacterial pathogens grown under 11 stress conditions, and identify common and unique regulatory responses, as well as processes participating in different stress responses.
Subject: 1184 Genetics, developmental biology, physiology
1182 Biochemistry, cell and molecular biology
ESCHERICHIA-COLI
GENE-EXPRESSION
BIOINFORMATICS DATABASE
SALMONELLA-TYPHIMURIUM
REGULATORY NETWORKS
IRON
SEQ
PROMOTER
PROTEIN
STRATEGIES
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


Files in this item

Total number of downloads: Loading...

Files Size Format View
s41467_021_23588_w.pdf 1.863Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record