RNA atlas of human bacterial pathogens uncovers stress dynamics linked to infection

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Avican , K , Aldahdooh , J , Togninalli , M , Mahmud , A K M F , Tang , J , Borgwardt , K M , Rhen , M & Fällman , M 2021 , ' RNA atlas of human bacterial pathogens uncovers stress dynamics linked to infection ' , Nature Communications , vol. 12 , no. 1 , 3282 . https://doi.org/10.1038/s41467-021-23588-w

Title: RNA atlas of human bacterial pathogens uncovers stress dynamics linked to infection
Author: Avican, Kemal; Aldahdooh, Jehad; Togninalli, Matteo; Mahmud, A. K. M. Firoj; Tang, Jing; Borgwardt, Karsten M.; Rhen, Mikael; Fällman, Maria
Contributor: University of Helsinki, Research Program in Systems Oncology
University of Helsinki, Institute for Molecular Medicine Finland
Date: 2021-06-02
Language: eng
Number of pages: 14
Belongs to series: Nature Communications
ISSN: 2041-1723
URI: http://hdl.handle.net/10138/331748
Abstract: Bacterial processes necessary for adaption to stressful host environments are potential targets for new antimicrobials. Here, we report large-scale transcriptomic analyses of 32 human bacterial pathogens grown under 11 stress conditions mimicking human host environments. The potential relevance of the in vitro stress conditions and responses is supported by comparisons with available in vivo transcriptomes of clinically important pathogens. Calculation of a probability score enables comparative cross-microbial analyses of the stress responses, revealing common and unique regulatory responses to different stresses, as well as overlapping processes participating in different stress responses. We identify conserved and species-specific ‘universal stress responders’, that is, genes showing altered expression in multiple stress conditions. Non-coding RNAs are involved in a substantial proportion of the responses. The data are collected in a freely available, interactive online resource (PATHOgenex).
Subject: 1182 Biochemistry, cell and molecular biology
1184 Genetics, developmental biology, physiology
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