Migraine in children and adults born preterm : A nationwide register linkage study

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Strang-Karlsson , S , Alenius , S , Näsänen-Gilmore , P , Nurhonen , M , Haaramo , P , Evensen , K A I , Vääräsmäki , M , Gissler , M , Hovi , P & Kajantie , E 2021 , ' Migraine in children and adults born preterm : A nationwide register linkage study ' , Cephalalgia , vol. 41 , no. 6 , pp. 677-689 . https://doi.org/10.1177/0333102420978357

Title: Migraine in children and adults born preterm : A nationwide register linkage study
Author: Strang-Karlsson, Sonja; Alenius, Suvi; Näsänen-Gilmore, Pieta; Nurhonen, Markku; Haaramo, Peija; Evensen, Kari Anne I.; Vääräsmäki, Marja; Gissler, Mika; Hovi, Petteri; Kajantie, Eero
Other contributor: University of Helsinki, HUSLAB
University of Helsinki, HUS Children and Adolescents
University of Helsinki, HUS Children and Adolescents
University of Helsinki, HUS Children and Adolescents







Date: 2021-05
Language: eng
Number of pages: 13
Belongs to series: Cephalalgia
ISSN: 0333-1024
DOI: https://doi.org/10.1177/0333102420978357
URI: http://hdl.handle.net/10138/331814
Abstract: Objective Being born preterm is related to adverse health effects later in life. We studied whether preterm birth predicts the risk of migraine. Methods In this nationwide register study, we linked data from six administrative registers for all 235,624 children live-born in Finland (January 1987 to September 1990) and recorded in the Finnish Medical Birth Register. n = 228,610 (97.0%) had adequate data and were included. Migraine served as primary outcome variable and was stringently defined as a diagnosis from specialised health care and/or >= 2 reimbursed purchases of triptans. We applied sex- and birth year-stratified Cox proportional hazard regression models to compute hazard ratios and confidence intervals (95% confidence intervals) for the association between preterm categories and migraine. The cohort was followed up until an average age of 25.1 years (range: 23.3-27.0). Results Among individuals born extremely preterm (23-27 completed weeks of gestation), the adjusted hazard ratios for migraine was 0.55 (0.25-1.24) when compared with the full-term reference group (39-41 weeks). The corresponding adjusted hazard ratios and 95% confidence intervals for the other preterm categories were: Very preterm (28-31 weeks); 0.95 (0.68-1.31), moderately preterm (32-33 weeks); 0.96 (0.73-1.27), late preterm (34-36 weeks); 1.01 (0.91-1.11), early term (37-38 weeks); 0.98 (0.93-1.03), and post term (42 weeks); 0.98 (0.89-1.08). Migraine was predicted by parental migraine, lower socioeconomic position, maternal hypertensive disorder and maternal smoking during pregnancy. Conclusion We found no evidence for a higher risk of migraine among individuals born preterm.
Subject: Neonatal
gestational age
cohort studies
epidemiology
adult outcomes
prematurity
TENSION-TYPE HEADACHE
YOUNG-ADULTS
HEART-DISEASE
BIRTH-WEIGHT
RISK-FACTORS
CHRONIC PAIN
METAANALYSIS
PREVALENCE
PREGNANCY
SMOKING
3123 Gynaecology and paediatrics
3112 Neurosciences
3124 Neurology and psychiatry
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