Clinical and Genetic Findings in 28 American Cocker Spaniels with Aural Ceruminous Gland Hyperplasia and Ectasia

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Pysyväisosoite

http://hdl.handle.net/10138/331817

Lähdeviite

Kaimio , M , Malkamäki , S , Kaukonen , M , Ahonen , S , Hytönen , M K , Rantala , M , Lohi , H , Saijonmaa-Koulumies , L & Laitinen-Vapaavuori , O 2021 , ' Clinical and Genetic Findings in 28 American Cocker Spaniels with Aural Ceruminous Gland Hyperplasia and Ectasia ' , Journal of Comparative Pathology , vol. 185 , pp. 30-44 . https://doi.org/10.1016/j.jcpa.2021.03.005

Julkaisun nimi: Clinical and Genetic Findings in 28 American Cocker Spaniels with Aural Ceruminous Gland Hyperplasia and Ectasia
Tekijä: Kaimio, Mirja; Malkamäki, Sanna; Kaukonen, Maria; Ahonen, Saija; Hytönen, Marjo K.; Rantala, Merja; Lohi, Hannes; Saijonmaa-Koulumies, Leena; Laitinen-Vapaavuori, Outi
Tekijän organisaatio: Equine and Small Animal Medicine
Veterinary Biosciences
Medicum
Hannes Tapani Lohi / Principal Investigator
Faculty of Veterinary Medicine
Departments of Faculty of Veterinary Medicine
Veterinary Teaching Hospital
Biosciences
Helsinki One Health (HOH)
Veterinary Genetics
Softis - pehmytkudossairaudet
Petbone – ortopedia, fysioterapia, kivunlievitys
Outi Vapaavuori / Principal Investigator
Päiväys: 2021-05
Kieli: eng
Sivumäärä: 15
Kuuluu julkaisusarjaan: Journal of Comparative Pathology
ISSN: 0021-9975
DOI-tunniste: https://doi.org/10.1016/j.jcpa.2021.03.005
URI: http://hdl.handle.net/10138/331817
Tiivistelmä: American Cocker Spaniels (ACSs) develop aural ceruminous gland hyperplasia and ectasia more often than dogs of other breeds. Data on the cause and development of these breed characteristic histopathological changes are lacking. We performed video-otoscopic examinations and dermatological work-up on 28 ACSs, obtained aural biopsies from each dog and assessed the statistical associations between the presence of ceruminous gland hyperplasia and ectasia and disease history, clinical or microbiological findings and underlying cause of otitis externa (OE). Histological lesions of ceruminous gland hyperplasia and ectasia were observed in aural biopsies from 6/13 clinically healthy ears and 13/15 ears with OE from 19/28 examined dogs. Nine of 28 dogs had histologically normal ceruminous glands (odds ratio [OR] 6.2, 95% confidence interval [CI] 1.1-36.6). Bacterial growth in microbiological culture of aural exudate (OR 14.1, 95% CI 2.1-95.3) was associated with ceruminous glandular changes, whereas previous history of OE, cutaneous findings or underlying allergies were not. Pedigree analysis and a genome-wide association study (GWAS) were performed on 18 affected and eight unaffected dogs based on histopathological diagnosis. While the GWAS indicated a tentative, but not statistically significant, association of ceruminous gland hyperplasia and ectasia with chromosome 31, a larger cohort is needed to confirm this preliminary result. Based on our results, ceruminous gland hyperplasia and ectasia may also precede clinical signs of OE in ACSs and a genetic aetiological component is likely Further studies with larger cohorts are warranted to verify our preliminary results. (C) 2021 The Authors. Published by Elsevier Ltd.
Avainsanat: American Cocker Spaniel
chromosome 31
histology
otitis externa
LATERAL BULLA OSTEOTOMY
EAR CANAL ABLATION
CANINE ATOPIC-DERMATITIS
OTITIS-EXTERNA
DOGS
ADHESION
FEATURES
DISEASE
CAR
413 Veterinary science
Vertaisarvioitu: Kyllä
Tekijänoikeustiedot: cc_by_nc_nd
Pääsyrajoitteet: openAccess
Rinnakkaistallennettu versio: publishedVersion


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