Clinical and Genetic Findings in 28 American Cocker Spaniels with Aural Ceruminous Gland Hyperplasia and Ectasia

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dc.contributor.author Kaimio, Mirja
dc.contributor.author Malkamäki, Sanna
dc.contributor.author Kaukonen, Maria
dc.contributor.author Ahonen, Saija
dc.contributor.author Hytönen, Marjo K.
dc.contributor.author Rantala, Merja
dc.contributor.author Lohi, Hannes
dc.contributor.author Saijonmaa-Koulumies, Leena
dc.contributor.author Laitinen-Vapaavuori, Outi
dc.date.accessioned 2021-06-24T12:27:01Z
dc.date.available 2021-06-24T12:27:01Z
dc.date.issued 2021-05
dc.identifier.citation Kaimio , M , Malkamäki , S , Kaukonen , M , Ahonen , S , Hytönen , M K , Rantala , M , Lohi , H , Saijonmaa-Koulumies , L & Laitinen-Vapaavuori , O 2021 , ' Clinical and Genetic Findings in 28 American Cocker Spaniels with Aural Ceruminous Gland Hyperplasia and Ectasia ' , Journal of Comparative Pathology , vol. 185 , pp. 30-44 . https://doi.org/10.1016/j.jcpa.2021.03.005
dc.identifier.other PURE: 165438129
dc.identifier.other PURE UUID: f9b112ba-5728-45de-ad26-d0ddb43a88eb
dc.identifier.other WOS: 000660063500004
dc.identifier.other ORCID: /0000-0003-1976-5874/work/96051656
dc.identifier.other ORCID: /0000-0003-3313-784X/work/96052010
dc.identifier.other ORCID: /0000-0002-2146-4694/work/96052774
dc.identifier.other ORCID: /0000-0001-6707-1581/work/96053197
dc.identifier.uri http://hdl.handle.net/10138/331817
dc.description.abstract American Cocker Spaniels (ACSs) develop aural ceruminous gland hyperplasia and ectasia more often than dogs of other breeds. Data on the cause and development of these breed characteristic histopathological changes are lacking. We performed video-otoscopic examinations and dermatological work-up on 28 ACSs, obtained aural biopsies from each dog and assessed the statistical associations between the presence of ceruminous gland hyperplasia and ectasia and disease history, clinical or microbiological findings and underlying cause of otitis externa (OE). Histological lesions of ceruminous gland hyperplasia and ectasia were observed in aural biopsies from 6/13 clinically healthy ears and 13/15 ears with OE from 19/28 examined dogs. Nine of 28 dogs had histologically normal ceruminous glands (odds ratio [OR] 6.2, 95% confidence interval [CI] 1.1-36.6). Bacterial growth in microbiological culture of aural exudate (OR 14.1, 95% CI 2.1-95.3) was associated with ceruminous glandular changes, whereas previous history of OE, cutaneous findings or underlying allergies were not. Pedigree analysis and a genome-wide association study (GWAS) were performed on 18 affected and eight unaffected dogs based on histopathological diagnosis. While the GWAS indicated a tentative, but not statistically significant, association of ceruminous gland hyperplasia and ectasia with chromosome 31, a larger cohort is needed to confirm this preliminary result. Based on our results, ceruminous gland hyperplasia and ectasia may also precede clinical signs of OE in ACSs and a genetic aetiological component is likely Further studies with larger cohorts are warranted to verify our preliminary results. (C) 2021 The Authors. Published by Elsevier Ltd. en
dc.format.extent 15
dc.language.iso eng
dc.relation.ispartof Journal of Comparative Pathology
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject American Cocker Spaniel
dc.subject chromosome 31
dc.subject histology
dc.subject otitis externa
dc.subject LATERAL BULLA OSTEOTOMY
dc.subject EAR CANAL ABLATION
dc.subject CANINE ATOPIC-DERMATITIS
dc.subject OTITIS-EXTERNA
dc.subject DOGS
dc.subject ADHESION
dc.subject FEATURES
dc.subject DISEASE
dc.subject CAR
dc.subject 413 Veterinary science
dc.title Clinical and Genetic Findings in 28 American Cocker Spaniels with Aural Ceruminous Gland Hyperplasia and Ectasia en
dc.type Article
dc.contributor.organization Equine and Small Animal Medicine
dc.contributor.organization Veterinary Biosciences
dc.contributor.organization Medicum
dc.contributor.organization Hannes Tapani Lohi / Principal Investigator
dc.contributor.organization Faculty of Veterinary Medicine
dc.contributor.organization Departments of Faculty of Veterinary Medicine
dc.contributor.organization Veterinary Teaching Hospital
dc.contributor.organization Biosciences
dc.contributor.organization Helsinki One Health (HOH)
dc.contributor.organization Veterinary Genetics
dc.contributor.organization Softis - pehmytkudossairaudet
dc.contributor.organization Petbone – ortopedia, fysioterapia, kivunlievitys
dc.contributor.organization Outi Vapaavuori / Principal Investigator
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.jcpa.2021.03.005
dc.relation.issn 0021-9975
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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