Serological Evidence of Human Orthohantavirus Infections in Barbados, 2008 to 2016

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http://hdl.handle.net/10138/331904

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Douglas , K O , Samuels , T A , Iheozor-Ejiofor , R , Vapalahti , O , Sironen , T & Gittens-St. Hilaire , M 2021 , ' Serological Evidence of Human Orthohantavirus Infections in Barbados, 2008 to 2016 ' , Pathogens , vol. 10 , no. 5 , 571 . https://doi.org/10.3390/pathogens10050571

Title: Serological Evidence of Human Orthohantavirus Infections in Barbados, 2008 to 2016
Author: Douglas, Kirk Osmond; Samuels, Thelma Alafia; Iheozor-Ejiofor, Rommel; Vapalahti, Olli; Sironen, Tarja; Gittens-St. Hilaire, Marquita
Contributor organization: Viral Zoonosis Research Unit
HUSLAB
Department of Virology
Veterinary Biosciences
Helsinki One Health (HOH)
Olli Pekka Vapalahti / Principal Investigator
Veterinary Microbiology and Epidemiology
Emerging Infections Research Group
Date: 2021-05
Language: eng
Number of pages: 18
Belongs to series: Pathogens
ISSN: 2076-0817
DOI: https://doi.org/10.3390/pathogens10050571
URI: http://hdl.handle.net/10138/331904
Abstract: Background: Hantavirus pulmonary syndrome (HPS) is well-known in South and North America; however, not enough data exist for the Caribbean. The first report of clinical orthohantavirus infection was obtained in Barbados, but no other evidence of clinical orthohantavirus infections among adults in the Caribbean has been documented. Methods: Using enzyme linked immunosorbent assay (ELISA) tests followed by confirmatory testing with immunofluorescent assays (IFA), immunochromatographic (ICG) tests, and pseudotype focus reduction neutralization tests (pFRNT), we retrospectively and prospectively detected orthohantavirus-specific antibodies among patients with febrile illness in Barbados. Results: The orthohantavirus prevalence rate varied from 5.8 to 102.6 cases per 100,000 persons among febrile patients who sought medical attention annually between 2008 and 2016. Two major orthohantavirus epidemics occurred in Barbados during 2010 and 2016. Peak orthohantavis infections were observed observed during the rainy season (August) and prevalence rates were significantly higher in females than males and in patients from urban parishes than rural parishes. Conclusions: Orthohantavirus infections are still occurring in Barbados and in some patients along with multiple pathogen infections (CHIKV, ZIKV, DENV and Leptospira). Orthohantavirus infections are more prevalent during periods of high rainfall (rainy season) with peak transmission in August; females are more likely to be infected than males and infections are more likely among patients from urban rather than rural parishes in Barbados.
Subject: HFRS
HPS
VHF
orthohantavirus
dengue
infectious disease
Caribbean
Americas
biosecurity
HANTAVIRUS PULMONARY SYNDROME
HEMORRHAGIC-FEVER
RENAL SYNDROME
INCUBATION PERIOD
SEOUL HANTAVIRUS
SAO-PAULO
VIRUS
TRANSMISSION
ARGENTINA
STATE
3111 Biomedicine
11832 Microbiology and virology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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