Lymphatic Vessels in Tumor Dissemination versus Immunotherapy

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Vaahtomeri , K & Alitalo , K 2020 , ' Lymphatic Vessels in Tumor Dissemination versus Immunotherapy ' , Cancer Research , vol. 80 , no. 17 , pp. 3463-3465 .

Title: Lymphatic Vessels in Tumor Dissemination versus Immunotherapy
Author: Vaahtomeri, Kari; Alitalo, Kari
Contributor organization: Cell Communication
Staff Services
CAN-PRO - Translational Cancer Medicine Program
University of Helsinki
Kari Alitalo / Principal Investigator
Research Programs Unit
Digital Precision Cancer Medicine (iCAN)
Date: 2020-09-01
Language: eng
Number of pages: 3
Belongs to series: Cancer Research
ISSN: 0008-5472
Abstract: During the growth of various cancers, primary tumors can escape antitumor immune responses of their host and eventually disseminate into distant organs. Peritumoral lymphatic vessels connect the primary tumor to lymph nodes, facilitating tumor entry into lymph nodes, systemic circulation, and metastasis. Lymph node metastases that occur frequently provide sites of tumor cell spread, whereas tumor antigen transfer into and presentation in tumor-draining lymph nodes induce activation of tumor-specific T-lymphocyte responses that can result in cytolytic targeting of the tumor. Here, we discuss the recently emerged controversial role of the lymphatic vessels in tumor dissemination and cancer immunotherapy.
3122 Cancers
Peer reviewed: No
Rights: unspecified
Usage restriction: openAccess
Self-archived version: acceptedVersion

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