Genetic variants for morningness in relation to habitual sleep-wake behavior and diurnal preference in a population-based sample of 17,243 adults

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Merikanto , I , Kantojärvi , K , Partonen , T , Pesonen , A-K & Paunio , T 2021 , ' Genetic variants for morningness in relation to habitual sleep-wake behavior and diurnal preference in a population-based sample of 17,243 adults ' , Sleep Medicine , vol. 80 , pp. 322-332 . https://doi.org/10.1016/j.sleep.2021.01.054

Title: Genetic variants for morningness in relation to habitual sleep-wake behavior and diurnal preference in a population-based sample of 17,243 adults
Author: Merikanto, Ilona; Kantojärvi, Katri; Partonen, Timo; Pesonen, Anu-Katriina; Paunio, Tiina
Contributor organization: SLEEPWELL Research Program
Department of Psychology and Logopedics
Department of Psychiatry
Mind and Matter
Behavioural Sciences
HUS Psychiatry
Date: 2021-04
Language: eng
Number of pages: 11
Belongs to series: Sleep Medicine
ISSN: 1389-9457
DOI: https://doi.org/10.1016/j.sleep.2021.01.054
URI: http://hdl.handle.net/10138/332033
Abstract: Objective Associations of eveningness with health hazards benefit from analyzing to what extent the polygenic score for morningness correlates with the assessments of the behavioral trait of morningness-eveningness and chronotype. Methods With a population-based sample of 17,243 Finnish adults, aged 25–74 years, this study examines the associations of four feasible assessment methods of chronotype, a) biological the genetic liability based on the polygenic score for morningness (PGSmorn), b) the widely-used single item for self-assessed morningness/eveningness (MEQi19) of the original Morningness-Eveningness Questionnaire (MEQ), c) the behavioral trait of morningness-eveningness as assessed with the score on the shortened version (sMEQ) of the original MEQ, and d) the phase of entrainment as assessed with the habitual midpoint of sleep based on the self-reported sleep-wake schedule during weekend (Sleepmid-wknd) as well as the sleep debt corrected midpoint of sleep (Sleepmid-corr). Results All self-report measures correlated with each other, but very weakly with the PGSmorn, which explained 1–2% of the variation in diurnal preference or habitual sleep-wake schedule. The influence of age was greater on Sleepmid-wknd and Sleepmid-corr than on the sMEQ or MEQi19, indicating that the diurnal preference might be a more stable indicator for morningness-eveningness than the sleep-wake schedule. Analyses of the discrepancies between sMEQ and MEQi19 indicated that eveningness can be over-estimated when relying on only the single-item self-assessment. Conclusions The current polygenic score for morningness explains only a small proportion of the variation in diurnal preference or habitual sleep-wake schedule. The molecular genetic basis for morningness-eveningness needs further elucidation.
Subject: 515 Psychology
3121 General medicine, internal medicine and other clinical medicine
3142 Public health care science, environmental and occupational health
Chronotype
Eveningness
MEQ
Polygenic risk score
Population-based
Sleep midpoint
CIRCADIAN PHASE
EVENINGNESS QUESTIONNAIRE
ENVIRONMENTAL-INFLUENCES
CARDIOVASCULAR-DISEASES
INCREASED ODDS
CHRONOTYPE
MELATONIN
PERIOD
ASSOCIATION
CONSISTENCY
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion


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