Neonatal neuroimaging and neurophysiology predict infantile onset epilepsy after perinatal hypoxic ischemic encephalopathy

Show simple item record Nevalainen, Päivi Metsäranta, Marjo Toiviainen-Salo, Sanna Marchi, Viviana Mikkonen, Kirsi Vanhatalo, Sampsa Lauronen, Leena 2021-07-03T22:26:10Z 2021-12-18T03:45:52Z 2020-08
dc.identifier.citation Nevalainen , P , Metsäranta , M , Toiviainen-Salo , S , Marchi , V , Mikkonen , K , Vanhatalo , S & Lauronen , L 2020 , ' Neonatal neuroimaging and neurophysiology predict infantile onset epilepsy after perinatal hypoxic ischemic encephalopathy ' , Seizure - European Journal of Epilepsy , vol. 80 , pp. 249-256 .
dc.identifier.other PURE: 145221875
dc.identifier.other PURE UUID: d62c40bd-185c-4f69-9afa-fb7883072b99
dc.identifier.other WOS: 000565178800052
dc.identifier.other ORCID: /0000-0003-1300-2323/work/86938396
dc.description Correction: Volume88, Page158-158 DOI10.1016/j.seizure.2021.04.001 PublishedMAY 2021
dc.description.abstract Purpose: To evaluate the accuracy of hypoxic ischemic encephalopathy (HIE) grade, and neonatal neurophysiological and neuroimaging measures for predicting development of infantile spasms syndrome (IS) or other postneonatal, infantile onset epilepsy after perinatal HIE. Methods: We examined a population-based cohort of 92 consequent infants with moderate-to-severe HIE. The HIE grade and neonatal neuroimaging (MRI) and neurophysiology (EEG and somatosensory evoked potentials, SEPs) findings were compared to the development of IS or other epilepsy within the first year of life. Results: Out of 74 surviving infants with follow-up information, five developed IS and one developed a focal onset epilepsy. They all had recovered from severe HIE. All survivors with inactive neonatal EEG (recorded within the first few postnatal days, n = 4) or the most severe type of brain injury in MRI (n = 3) developed epilepsy (positive predictive value, PPV 100 %). Bilaterally absent SEPs had 100 % sensitivity and 75 % PPV for epilepsy. A combination of absent SEPs and a poor MRI finding (combined deep and cortical gray matter injury) resulted in higher PPV (86 %) without lowering sensitivity (100 %). Follow-up EEGs showed recurrent epileptiform activity already between 1- and 2-months age in those that developed epilepsy, distinguishing them from those surviving without epilepsy. Conclusions: Poor neonatal neuroimaging and neurophysiological findings provide accurate prediction for development of infantile onset epilepsy after HIE. Of the neonates with severe HIE, the ones with severe neonatal MRI and neurophysiological abnormalities need frequent follow-up, including repeated EEGs, for early detection of IS. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof Seizure - European Journal of Epilepsy
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Infantile spasms syndrome (IS)
dc.subject Perinatal hypoxic ischemic encephalopathy
dc.subject Electroencephalography (EEG)
dc.subject Somatosensory evoked potentials (SEPs)
dc.subject Magnetic resonance imaging (MRI)
dc.subject WEST-SYNDROME
dc.subject SPASMS
dc.subject EVOLUTION
dc.subject AEEG
dc.subject NEWBORNS
dc.subject RISK
dc.subject TERM
dc.subject 3112 Neurosciences
dc.subject 3124 Neurology and psychiatry
dc.title Neonatal neuroimaging and neurophysiology predict infantile onset epilepsy after perinatal hypoxic ischemic encephalopathy en
dc.type Article
dc.contributor.organization HUS Medical Imaging Center
dc.contributor.organization BioMag Laboratory
dc.contributor.organization Department of Neurosciences
dc.contributor.organization Kliinisen neurofysiologian yksikkö
dc.contributor.organization Children's Hospital
dc.contributor.organization Department of Diagnostics and Therapeutics
dc.contributor.organization University of Helsinki
dc.contributor.organization Helsinki University Hospital Area
dc.contributor.organization HUS Children and Adolescents
dc.contributor.organization Lastenneurologian yksikkö
dc.contributor.organization Clinicum
dc.description.reviewstatus Peer reviewed
dc.relation.issn 1059-1311
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion

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