Adverse prognostic impact of regulatory T-cells in testicular diffuse large B-cell lymphoma

Näytä kaikki kuvailutiedot



Pysyväisosoite

http://hdl.handle.net/10138/332255

Lähdeviite

Pollari , M , Pellinen , T , Karjalainen-Lindsberg , M-L , Kellokumpu-Lehtinen , P-L , Leivonen , S-K & Leppä , S 2020 , ' Adverse prognostic impact of regulatory T-cells in testicular diffuse large B-cell lymphoma ' , European Journal of Haematology , vol. 105 , no. 6 , pp. 712-721 . https://doi.org/10.1111/ejh.13484

Julkaisun nimi: Adverse prognostic impact of regulatory T-cells in testicular diffuse large B-cell lymphoma
Tekijä: Pollari, Marjukka; Pellinen, Teijo; Karjalainen-Lindsberg, Marja-Liisa; Kellokumpu-Lehtinen, Pirkko-Liisa; Leivonen, Suvi-Katri; Leppä, Sirpa
Tekijän organisaatio: Research Programs Unit
Faculty of Medicine
University of Helsinki
Precision Systems Medicine
Institute for Molecular Medicine Finland
HUS Comprehensive Cancer Center
Medicum
Department of Pathology
Helsinki University Hospital Area
Genome-Scale Biology (GSB) Research Program
Department of Oncology
Clinicum
Digital Precision Cancer Medicine (iCAN)
Päiväys: 2020-12
Kieli: eng
Sivumäärä: 10
Kuuluu julkaisusarjaan: European Journal of Haematology
ISSN: 0902-4441
DOI-tunniste: https://doi.org/10.1111/ejh.13484
URI: http://hdl.handle.net/10138/332255
Tiivistelmä: Objectives Testicular diffuse large B-cell lymphoma (T-DLBCL) is a rare and aggressive extranodal lymphoma. We have previously shown that high content of tumor-infiltrating lymphocytes (TILs) and PD-1 expressing TILs associate with better survival in T-DLBCL. In this study, we have further characterized distinct TIL subtypes and their proportions in association with patient demographics and survival. Methods We used multiplex immunohistochemistry to characterize TIL phenotypes, including cytotoxic T-cells (CTLs; CD8(+), OX40(+), Granzyme B+, Ki-67(+), LAG-3(+), TIM-3(+), PD-1(+)), CD4(+)T-cells (CD3(+), CD4(+), TIM-3(+), LAG-3(+)), regulatory T-cells (Tregs; CD3(+), CD4(+), FoxP3(+)), and T helper 1 cells (Th1; CD3(+), CD4(+), T-bet(+)) in 79 T-DLBCLs, and correlated the findings with patient demographics and outcome. Results We observed a substantial variation in TIL phenotypes between the patients. The most prominent CD8(+)TILs were Ki-67(+)and TIM-3(+)CTLs, whereas the most prominent CD4(+)TILs were FoxP3(+)Tregs. Despite the overall favorable prognostic impact of high TIL content, we found a subpopulation of T-bet(+)FoxP3(+)Tregs that had a significant adverse impact on survival. Lower content of CTLs with activated or exhausted phenotypes correlated with aggressive clinical features. Conclusions Our results demonstrate significant variation in TIL phenotypes and emphasize the adverse prognostic impact of Tregs in T-DLBCL.
Avainsanat: lymphoma
regulatory T-cell
testicular diffuse large B-cell lymphoma
tumor-infiltrating lymphocyte
CENTRAL-NERVOUS-SYSTEM
CLASS-II EXPRESSION
TUMOR MICROENVIRONMENT
TRANSCRIPTION FACTOR
FEATURES
HODGKIN
PD-1
BET
TOLERANCE
BLOCKADE
3122 Cancers
Vertaisarvioitu: Kyllä
Pääsyrajoitteet: openAccess
Rinnakkaistallennettu versio: acceptedVersion


Tiedostot

Latausmäärä yhteensä: Ladataan...

Tiedosto(t) Koko Formaatti Näytä
Adverse_prognos ... _large_B_cell_lymphoma.pdf 35.75MB PDF Avaa tiedosto

Viite kuuluu kokoelmiin:

Näytä kaikki kuvailutiedot