Adverse prognostic impact of regulatory T-cells in testicular diffuse large B-cell lymphoma

Visa fullständig post



Pollari , M , Pellinen , T , Karjalainen-Lindsberg , M-L , Kellokumpu-Lehtinen , P-L , Leivonen , S-K & Leppä , S 2020 , ' Adverse prognostic impact of regulatory T-cells in testicular diffuse large B-cell lymphoma ' , European Journal of Haematology , vol. 105 , no. 6 , pp. 712-721 .

Titel: Adverse prognostic impact of regulatory T-cells in testicular diffuse large B-cell lymphoma
Författare: Pollari, Marjukka; Pellinen, Teijo; Karjalainen-Lindsberg, Marja-Liisa; Kellokumpu-Lehtinen, Pirkko-Liisa; Leivonen, Suvi-Katri; Leppä, Sirpa
Upphovmannens organisation: Research Programs Unit
Faculty of Medicine
University of Helsinki
Precision Systems Medicine
Institute for Molecular Medicine Finland
HUS Comprehensive Cancer Center
Department of Pathology
Helsinki University Hospital Area
Genome-Scale Biology (GSB) Research Program
Department of Oncology
Digital Precision Cancer Medicine (iCAN)
Datum: 2020-12
Språk: eng
Sidantal: 10
Tillhör serie: European Journal of Haematology
ISSN: 0902-4441
Permanenta länken (URI):
Abstrakt: Objectives Testicular diffuse large B-cell lymphoma (T-DLBCL) is a rare and aggressive extranodal lymphoma. We have previously shown that high content of tumor-infiltrating lymphocytes (TILs) and PD-1 expressing TILs associate with better survival in T-DLBCL. In this study, we have further characterized distinct TIL subtypes and their proportions in association with patient demographics and survival. Methods We used multiplex immunohistochemistry to characterize TIL phenotypes, including cytotoxic T-cells (CTLs; CD8(+), OX40(+), Granzyme B+, Ki-67(+), LAG-3(+), TIM-3(+), PD-1(+)), CD4(+)T-cells (CD3(+), CD4(+), TIM-3(+), LAG-3(+)), regulatory T-cells (Tregs; CD3(+), CD4(+), FoxP3(+)), and T helper 1 cells (Th1; CD3(+), CD4(+), T-bet(+)) in 79 T-DLBCLs, and correlated the findings with patient demographics and outcome. Results We observed a substantial variation in TIL phenotypes between the patients. The most prominent CD8(+)TILs were Ki-67(+)and TIM-3(+)CTLs, whereas the most prominent CD4(+)TILs were FoxP3(+)Tregs. Despite the overall favorable prognostic impact of high TIL content, we found a subpopulation of T-bet(+)FoxP3(+)Tregs that had a significant adverse impact on survival. Lower content of CTLs with activated or exhausted phenotypes correlated with aggressive clinical features. Conclusions Our results demonstrate significant variation in TIL phenotypes and emphasize the adverse prognostic impact of Tregs in T-DLBCL.
Subject: lymphoma
regulatory T-cell
testicular diffuse large B-cell lymphoma
tumor-infiltrating lymphocyte
3122 Cancers
Referentgranskad: Ja
Användningsbegränsning: openAccess
Parallelpublicerad version: acceptedVersion

Filer under denna titel

Totalt antal nerladdningar: Laddar...

Filer Storlek Format Granska
Adverse_prognos ... _large_B_cell_lymphoma.pdf 35.75Mb PDF Granska/Öppna

Detta dokument registreras i samling:

Visa fullständig post