Anticancer effects of lingonberry and bilberry on digestive tract cancers

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Onali , T , Kivimäki , A , Mauramo , M , Salo , T & Korpela , R 2021 , ' Anticancer effects of lingonberry and bilberry on digestive tract cancers ' , Antioxidants , vol. 10 , no. 6 , 850 . https://doi.org/10.3390/antiox10060850

Title: Anticancer effects of lingonberry and bilberry on digestive tract cancers
Author: Onali, Tuulia; Kivimäki, Anne; Mauramo, Matti; Salo, Tuula; Korpela, Riitta
Contributor organization: Department of Oral and Maxillofacial Diseases
Faculty of Medicine
University of Helsinki
Department of Pharmacology
Medicum
Department of Pathology
HUSLAB
HUS Head and Neck Center
Helsinki University Hospital Area
TRIMM - Translational Immunology Research Program
Riitta Anneli Korpela / Principal Investigator
HUMI - Human Microbiome Research
Research Programs Unit
Date: 2021-06
Language: eng
Number of pages: 17
Belongs to series: Antioxidants
ISSN: 2076-3921
DOI: https://doi.org/10.3390/antiox10060850
URI: http://hdl.handle.net/10138/332362
Abstract: Wild berries are part of traditional Nordic diets and are a rich source of phytochemicals, such as polyphenols. Various berry treatments have shown to interfere with cancer progression in vitro and in vivo. Here, we systematically reviewed the anticancer effects of two Nordic wild berries of the Vaccinium genus, lingonberry (Vaccinium vitis-idaea) and bilberry (Vaccinium myrtillus), on digestive tract cancers. The review was conducted according to the PRISMA 2020 guidelines. Searches included four databases: PubMed, Scopus, Web of Science, and CAB abstracts. Publications not written in English, case-reports, reviews, and conference abstracts were excluded. Moreover, studies with only indirect markers of cancer risk or studies with single compounds not derived from lingonberry or bilberry were not included. Meta-analysis was not performed. The majority (21/26) of studies investigated bilberry and colorectal cancer. Experimental studies on colorectal cancer indicated that bilberry inhibited intestinal tumor formation and cancer cell growth. One uncontrolled pilot human study supported the inhibitory potential of bilberry on colorectal cancer cell proliferation. Data from all 10 lingonberry studies suggests potent inhibition of cancer cell growth and tumor formation. In conclusion, in vitro and animal models support the antiproliferative and antitumor effects of various bilberry and lingonberry preparations on digestive tract cancers.
Description: cited By 0
Subject: 416 Food Science
3111 Biomedicine
1182 Biochemistry, cell and molecular biology
317 Pharmacy
lingonberry
bilberry
colorectal cancer
oral cancer
proliferation
invasion
migration
tumorigenesis
phytochemical
polyphenol
anthocyanin
proanthocyanidin
ANTHOCYANIN-RICH EXTRACTS
COLON-CANCER
VACCINIUM-MYRTILLUS
IN-VITRO
PHENOLIC COMPOSITION
BERRY EXTRACTS
CELL-LINES
ANTIOXIDANT
POLYPHENOLS
INHIBITION
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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