Comparison of anadromous and landlocked Atlantic salmon genomes reveals signatures of parallel and relaxed selection across the Northern Hemisphere

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dc.contributor.author Kjaerner-Semb, Erik
dc.contributor.author Edvardsen, Rolf B.
dc.contributor.author Ayllon, Fernando
dc.contributor.author Vogelsang, Petra
dc.contributor.author Furmanek, Tomasz
dc.contributor.author Rubin, Carl Johan
dc.contributor.author Veselov, Alexey E.
dc.contributor.author Nilsen, Tom Ole
dc.contributor.author McCormick, Stephen D.
dc.contributor.author Primmer, Craig R.
dc.contributor.author Wargelius, Anna
dc.date.accessioned 2021-07-12T14:26:01Z
dc.date.available 2021-07-12T14:26:01Z
dc.date.issued 2021-02
dc.identifier.citation Kjaerner-Semb , E , Edvardsen , R B , Ayllon , F , Vogelsang , P , Furmanek , T , Rubin , C J , Veselov , A E , Nilsen , T O , McCormick , S D , Primmer , C R & Wargelius , A 2021 , ' Comparison of anadromous and landlocked Atlantic salmon genomes reveals signatures of parallel and relaxed selection across the Northern Hemisphere ' , Evolutionary Applications , vol. 14 , no. 2 , pp. 446-461 . https://doi.org/10.1111/eva.13129
dc.identifier.other PURE: 149396125
dc.identifier.other PURE UUID: ef398a51-27c6-4e72-9106-8b133a705381
dc.identifier.other WOS: 000572067300001
dc.identifier.other ORCID: /0000-0002-3687-8435/work/96892161
dc.identifier.uri http://hdl.handle.net/10138/332374
dc.description.abstract Most Atlantic salmon (Salmo salarL.) populations follow an anadromous life cycle, spending early life in freshwater, migrating to the sea for feeding, and returning to rivers to spawn. At the end of the last ice age similar to 10,000 years ago, several populations of Atlantic salmon became landlocked. Comparing their genomes to their anadromous counterparts can help identify genetic variation related to either freshwater residency or anadromy. The objective of this study was to identify consistently divergent loci between anadromous and landlocked Atlantic salmon strains throughout their geographical distribution, with the long-term aim of identifying traits relevant for salmon aquaculture, including fresh and seawater growth, omega-3 metabolism, smoltification, and disease resistance. We used a Pool-seq approach (n = 10-40 individuals per population) to sequence the genomes of twelve anadromous and six landlocked Atlantic salmon populations covering a large part of the Northern Hemisphere and conducted a genomewide association study to identify genomic regions having been under different selection pressure in landlocked and anadromous strains. A total of 28 genomic regions were identified and includedcadm1on Chr 13 andppargc1aon Chr 18. Seven of the regions additionally displayed consistently reduced heterozygosity in fish obtained from landlocked populations, including the genes gpr132, cdca4, and sertad2 on Chr 15. We also found 16 regions, includingigf1on Chr 17, which consistently display reduced heterozygosity in the anadromous populations compared to the freshwater populations, indicating relaxed selection on traits associated with anadromy in landlocked salmon. In conclusion, we have identified 37 regions which may harbor genetic variation relevant for improving fish welfare and quality in the salmon farming industry and for understanding life-history traits in fish. en
dc.format.extent 16
dc.language.iso eng
dc.relation.ispartof Evolutionary Applications
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject disease resistance
dc.subject freshwater resident
dc.subject GWAS
dc.subject pool sequencing
dc.subject Salmo salar
dc.subject seawater adaptation
dc.subject selective sweeps
dc.subject smoltification
dc.subject SINGLE NUCLEOTIDE POLYMORPHISMS
dc.subject GROWTH-FACTOR-I
dc.subject COHO SALMON
dc.subject GENE-EXPRESSION
dc.subject SALAR
dc.subject SEQUENCE
dc.subject HORMONE
dc.subject DEFICIENCY
dc.subject METABOLISM
dc.subject ACTIVATION
dc.subject 1181 Ecology, evolutionary biology
dc.title Comparison of anadromous and landlocked Atlantic salmon genomes reveals signatures of parallel and relaxed selection across the Northern Hemisphere en
dc.type Article
dc.contributor.organization Helsinki Institute of Sustainability Science (HELSUS)
dc.contributor.organization Evolution, Conservation, and Genomics
dc.contributor.organization Institute of Biotechnology
dc.contributor.organization Organismal and Evolutionary Biology Research Programme
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1111/eva.13129
dc.relation.issn 1752-4571
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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