Association of Picornavirus Infections With Acute Otitis Media in a Prospective Birth Cohort Study

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DIABIMMUNE Study Grp , Seppälä , E M , Oikarinen , S , Lehtonen , J P , Neupane , S , Honkanen , H , Tyni , I , Siljander , H , Ilonen , J , Sillanpää , S , Laranne , J , Knip , M & Hyöty , H 2020 , ' Association of Picornavirus Infections With Acute Otitis Media in a Prospective Birth Cohort Study ' , Journal of Infectious Diseases , vol. 222 , no. 2 , pp. 324-332 .

Title: Association of Picornavirus Infections With Acute Otitis Media in a Prospective Birth Cohort Study
Author: DIABIMMUNE Study Grp; Seppälä, Elina M.; Oikarinen, Sami; Lehtonen, Jussi P.; Neupane, Subas; Honkanen, Hanna; Tyni, Iiris; Siljander, Heli; Ilonen, Jorma; Sillanpää, Saara; Laranne, Jussi; Knip, Mikael; Hyöty, Heikki
Contributor organization: Clinicum
HUS Children and Adolescents
Children's Hospital
Research Programs Unit
CAMM - Research Program for Clinical and Molecular Metabolism
Faculty of Medicine
University of Helsinki
Date: 2020-07-15
Language: eng
Number of pages: 9
Belongs to series: Journal of Infectious Diseases
ISSN: 0022-1899
Abstract: Background. Human rhinoviruses (HRVs), human enteroviruses (HEVs) and human parechoviruses (HPeVs) have been linked to acute otitis media (AOM). We evaluated this association in a prospective birth cohort setting. Methods. A total of 324 healthy infants were followed up from birth to age 3 years. Nasal swab samples were collected at age 3, 6, 12, 18, 24, and 36 months and screened for HRV and HEV using real-time reverse-transcription quantitative polymerase chain reaction. Stool samples were collected monthly and analyzed for HRV, HEV, and HPeV. AOM episodes diagnosed by physicians were reported by parents in a diary. The association of viruses with AOM was analyzed using generalized estimation equations, and their relative contributions using population-attributable risk percentages. Results. A clear association was found between AOM episodes and simultaneous detection of HEV (adjusted odds ratio for the detection of virus in stools, 2.04; 95% confidence interval, 1.06-3.91) and HRV (1.54; 1.04-2.30). HPeV showed a similar, yet nonsignificant trend (adjusted odds ratio, 1.44; 95% confidence interval, .81-2.56). HRV and HEV showed higher population-attributable risk percentages (25% and 20%) than HPeV (11%). Conclusions. HEVs and HRVs may contribute to the development of AOM in a relatively large proportion of cases.
Subject: acute otitis media
human rhinovirus
human enterovirus
human parechovirus
3121 General medicine, internal medicine and other clinical medicine
11832 Microbiology and virology
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: acceptedVersion

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