The EU Child Cohort Network’s core data: establishing a set of findable, accessible, interoperable and re-usable (FAIR) variables

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http://hdl.handle.net/10138/332440

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LifeCycle Project Group , Pinot de Moira , A , Haakma , S , Strandberg-Larsen , K , Eriksson , J G , Mikkola , T M & Nybo Andersen , A-M 2021 , ' The EU Child Cohort Network’s core data: establishing a set of findable, accessible, interoperable and re-usable (FAIR) variables ' , European Journal of Epidemiology , vol. 36 , no. 5 , pp. 565-580 . https://doi.org/10.1007/s10654-021-00733-9

Julkaisun nimi: The EU Child Cohort Network’s core data: establishing a set of findable, accessible, interoperable and re-usable (FAIR) variables
Tekijä: LifeCycle Project Group; Pinot de Moira, Angela; Haakma, Sido; Strandberg-Larsen, Katrine; Eriksson, Johan G.; Mikkola, Tuija M.; Nybo Andersen, Anne-Marie
Tekijän organisaatio: Clinicum
Research Programs Unit
Johan Eriksson / Principal Investigator
Department of General Practice and Primary Health Care
Faculty of Medicine
University of Helsinki
Päiväys: 2021-05
Kieli: eng
Sivumäärä: 16
Kuuluu julkaisusarjaan: European Journal of Epidemiology
ISSN: 1573-7284
DOI-tunniste: https://doi.org/10.1007/s10654-021-00733-9
URI: http://hdl.handle.net/10138/332440
Tiivistelmä: The Horizon2020 LifeCycle Project is a cross-cohort collaboration which brings together data from multiple birth cohorts from across Europe and Australia to facilitate studies on the influence of early-life exposures on later health outcomes. A major product of this collaboration has been the establishment of a FAIR (findable, accessible, interoperable and reusable) data resource known as the EU Child Cohort Network. Here we focus on the EU Child Cohort Network’s core variables. These are a set of basic variables, derivable by the majority of participating cohorts and frequently used as covariates or exposures in lifecourse research. First, we describe the process by which the list of core variables was established. Second, we explain the protocol according to which these variables were harmonised in order to make them interoperable. Third, we describe the catalogue developed to ensure that the network’s data are findable and reusable. Finally, we describe the core data, including the proportion of variables harmonised by each cohort and the number of children for whom harmonised core data are available. EU Child Cohort Network data will be analysed using a federated analysis platform, removing the need to physically transfer data and thus making the data more accessible to researchers. The network will add value to participating cohorts by increasing statistical power and exposure heterogeneity, as well as facilitating cross-cohort comparisons, cross-validation and replication. Our aim is to motivate other cohorts to join the network and encourage the use of the EU Child Cohort Network by the wider research community.
Avainsanat: 3142 Public health care science, environmental and occupational health
Birth cohort
Cross-cohort collaboration
Lifecourse epidemiology
Data harmonisation
FAIR (findable
accessible
interoperable and reusable) principles
BIRTH-WEIGHT
DNA METHYLATION
DATA HARMONIZATION
NORWEGIAN MOTHER
AIR-POLLUTION
PRETERM BIRTH
PREGNANCY
PROFILE
HEALTH
GROWTH
Vertaisarvioitu: Kyllä
Tekijänoikeustiedot: cc_by
Pääsyrajoitteet: openAccess
Rinnakkaistallennettu versio: publishedVersion


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