Bello , I O , Almangush , A , Heikkinen , I , Haglund , C , Coletta , R D , Kowalski , L P , Makitie , A A , Nieminen , P , Leivo , I & Salo , T 2020 , ' Histological characteristics of early-stage oral tongue cancer in young versus older patients : A multicenter matched-pair analysis ' , Oral Diseases , vol. 26 , no. 5 , pp. 1081-1085 . https://doi.org/10.1111/odi.13288
Title: | Histological characteristics of early-stage oral tongue cancer in young versus older patients : A multicenter matched-pair analysis |
Author: | Bello, Ibrahim O.; Almangush, Alhadi; Heikkinen, Ilkka; Haglund, Caj; Coletta, Ricardo D.; Kowalski, Luiz P.; Makitie, Antti A.; Nieminen, Pentti; Leivo, Ilmo; Salo, Tuula |
Contributor organization: | Department of Pathology HUS Head and Neck Center Oral and Maxillofacial Surgery Medicum Department of Surgery Doctoral Programme in Biomedicine Doctoral Programme in Clinical Research Doctoral Programme in Oral Sciences Clinicum II kirurgian klinikka HUS Abdominal Center Department of Ophthalmology and Otorhinolaryngology University Management HUSLAB Department of Oral and Maxillofacial Diseases |
Date: | 2020-07 |
Language: | eng |
Number of pages: | 5 |
Belongs to series: | Oral Diseases |
ISSN: | 1354-523X |
DOI: | https://doi.org/10.1111/odi.13288 |
URI: | http://hdl.handle.net/10138/332715 |
Abstract: | Little is known about the histopathological characteristics that may differentiate early oral tongue cancer (OTSCC) between young and older patients. From a total of 311 cases diagnosed with clinically early-stage OTSCC at 6 institutions, only 42 patients were young patients were aged 60 years old were matched for center of management, clinical stage and gender. We compared epithelial and stromal histopathologic parameters between the two groups. Most of the parameters were similar between the two groups, although the young patients appeared to have marginally higher intensity of tumor budding, histologic risk score, infiltrative pattern of invasion and tumor-stroma ratio. However, none of the factors showed significant difference when comparing the two groups. The histological parameters reflect mechanisms of invasive growth and tissue response to invasive growth, but not the etiological difference in OTSCC between young and older patients. Further investigations are necessary to compare the genetic background of early OTSCC in the two groups. |
Subject: |
early-stage
histopathological characteristics matched-pair analysis oral tongue cancer young SQUAMOUS-CELL CARCINOMA WORST PATTERN RISK-FACTORS INVASION DEPTH 3122 Cancers |
Peer reviewed: | Yes |
Usage restriction: | openAccess |
Self-archived version: | acceptedVersion |
Total number of downloads: Loading...
Files | Size | Format | View |
---|---|---|---|
Histological_ch ... _matched_pair_analysis.pdf | 7.538Mb |
View/ |