Risk factors for major adverse cardiovascular events after the first acute coronary syndrome

Show full item record



Permalink

http://hdl.handle.net/10138/332745

Citation

Okkonen , M , Havulinna , A S , Ukkola , O , Huikuri , H , Pietilä , A , Koukkunen , H , Lehto , S , Mustonen , J , Ketonen , M , Airaksinen , J , Kesäniemi , Y A & Salomaa , V 2021 , ' Risk factors for major adverse cardiovascular events after the first acute coronary syndrome ' , Annals of Medicine , vol. 53 , no. 1 , pp. 817-823 . https://doi.org/10.1080/07853890.2021.1924395

Title: Risk factors for major adverse cardiovascular events after the first acute coronary syndrome
Author: Okkonen, Marjo; Havulinna, Aki S.; Ukkola, Olavi; Huikuri, Heikki; Pietilä, Arto; Koukkunen, Heli; Lehto, Seppo; Mustonen, Juha; Ketonen, Matti; Airaksinen, Juhani; Kesäniemi, Y. Antero; Salomaa, Veikko
Contributor organization: Medicum
Institute for Molecular Medicine Finland
Complex Disease Genetics
Date: 2021-01-01
Language: eng
Number of pages: 7
Belongs to series: Annals of Medicine
ISSN: 0785-3890
DOI: https://doi.org/10.1080/07853890.2021.1924395
URI: http://hdl.handle.net/10138/332745
Abstract: Aims To evaluate risk factors for major adverse cardiac event (MACE) after the first acute coronary syndrome (ACS) and to examine the prevalence of risk factors in post-ACS patients. Methods We used Finnish population-based myocardial infarction register, FINAMI, data from years 1993-2011 to identify survivors of first ACS (n = 12686), who were then followed up for recurrent events and all-cause mortality for three years. Finnish FINRISK risk factor surveys were used to determine the prevalence of risk factors (smoking, hyperlipidaemia, diabetes and blood pressure) in post-ACS patients (n = 199). Results Of the first ACS survivors, 48.4% had MACE within three years of their primary event, 17.0% were fatal. Diabetes (p = 4.4 x 10(-7)), heart failure (HF) during the first ACS attack hospitalization (p = 6.8 x 10(-15)), higher Charlson index (p = 1.56 x 10(-19)) and older age (p = .026) were associated with elevated risk for MACE in the three-year follow-up, and revascularization (p = .0036) was associated with reduced risk. Risk factor analyses showed that 23% of ACS survivors continued smoking and cholesterol levels were still high (>5mmol/l) in 24% although 86% of the patients were taking lipid lowering medication. Conclusion Diabetes, higher Charlson index and HF are the most important risk factors of MACE after the first ACS. Cardiovascular risk factor levels were still high among survivors of first ACS.
Subject: Epidemiology
acute coronary syndromes
prevention
major adverse cardiac event
ACUTE MYOCARDIAL-INFARCTION
HOSPITAL DISCHARGE REGISTER
EUROPEAN-SOCIETY
HEART-DISEASE
PREDICTORS
VALIDITY
PREVENTION
MORBIDITY
PROGNOSIS
MORTALITY
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


Files in this item

Total number of downloads: Loading...

Files Size Format View
Risk_factors_fo ... cute_coronary_syndrome.pdf 1.726Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record