Increased iron content in the heart of the Fmr1 knockout mouse

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http://hdl.handle.net/10138/332746

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Talvio , K , Kanninen , K M , White , A R , Koistinaho , J & Castren , M L 2021 , ' Increased iron content in the heart of the Fmr1 knockout mouse ' , BioMetals , vol. 34 , no. 4 , pp. 947-954 . https://doi.org/10.1007/s10534-021-00320-1

Title: Increased iron content in the heart of the Fmr1 knockout mouse
Author: Talvio, Karo; Kanninen, Katja M.; White, Anthony R.; Koistinaho, Jari; Castren, Maija L.
Contributor: University of Helsinki, Faculty of Medicine
University of Helsinki, Neuroscience Center
University of Helsinki, Department of Physiology
Date: 2021-08
Language: eng
Number of pages: 8
Belongs to series: BioMetals
ISSN: 0966-0844
URI: http://hdl.handle.net/10138/332746
Abstract: Trace elements have important functions in several processes involved in cellular homeostasis and survival. Dysfunctional metal ion homeostasis can make an important impact on cellular defence mechanisms. We assessed the concentrations of 23 trace minerals in different tissues (brain, spleen, heart and liver) of Fmr1 knockout (KO) mice that display the main phenotype of Fragile X syndrome (FXS), an intellectual disability syndrome and the best-known monogenic model of autism spectrum disorder (ASD). Altogether, seven minerals-Cu, Fe, K, Mg, Mn, Na, and P-were above the detection limit with the analysis revealing increased iron content in the heart of Fmr1 KO mice. In addition, levels of iron were higher in the cerebellum of the transgenic mouse when compared to wild type controls. These results implicate a role for dysregulated iron homeostasis in FXS tissues and suggest that defective iron-related mechanisms contribute to increased tissue vulnerability in FXS.
Subject: Trace elements
Metals
Autism
Fragile X syndrome
ENVIRONMENTAL RISK-FACTORS
AUTISM SPECTRUM DISORDERS
FRAGILE-X
CHILDREN
GENE
DEFICIENCY
COPPER
MICE
1182 Biochemistry, cell and molecular biology
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