Effects of Heating-needle Stimulation in Restoration of Weakened Descending Inhibition of Nociception in a Rat Model of Parkinson's Disease

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Lei , J , Ye , G , Pertovaara , A & You , H-J 2020 , ' Effects of Heating-needle Stimulation in Restoration of Weakened Descending Inhibition of Nociception in a Rat Model of Parkinson's Disease ' , Neuroscience , vol. 440 , pp. 249-266 . https://doi.org/10.1016/j.neuroscience.2020.05.043

Title: Effects of Heating-needle Stimulation in Restoration of Weakened Descending Inhibition of Nociception in a Rat Model of Parkinson's Disease
Author: Lei, Jing; Ye, Gang; Pertovaara, Antti; You, Hao-Jun
Contributor: University of Helsinki, Medicum
University of Helsinki, Antti Pertovaara / Principal Investigator
Date: 2020-08-01
Language: eng
Number of pages: 18
Belongs to series: Neuroscience
ISSN: 0306-4522
URI: http://hdl.handle.net/10138/332767
Abstract: Here we investigated variations of endogenous descending modulation of nociception and therapeutic effects of intramuscular (i.m.) heating-needle stimulation in early stage of Parkinson's disease (PD) induced by unilateral microinjection of 3.5 mu l of 2.5 mu g/mu l 6-hydroxydopamine into the rat striatum. Paw withdrawal reflexes to noxious mechanical and heat stimuli in PD rats with and without exposure to i.m. 5.8% saline induced muscle nociception were evaluated. Experimental PD had no influence on mechanical or heat sensitivity in the baseline condition, whereas descending facilitation was stronger and descending inhibition was weaker in PD rats than vehicle-treated or naive rats during muscle nociception (P <0.05). Striatal administration of 5 mu g of dopamine failed to reverse the PD-associated changes in descending facilitation or inhibition, whereas dopamine in the thalamic mediodorsal (MD) nucleus and ventromedial (VM) nucleus significantly decreased the increase in descending facilitation and reversed the attenuation in descending inhibition, respectively (P <0.05). I.m. 43 degrees C of heating-needle stimulation had no effects on the enhanced descending facilitation in PD rats, but it markedly increased descending inhibition and reversed the increase in the number of apomorphine-induced body rotations (P <0.05), which effects were dose-dependently attenuated by raclopride, a dopamine 2 receptor antagonist, in the thalamic VM nucleus (P <0.05). The results indicate that the early-stage PD is associated with enhanced descending facilitation and weakened descending inhibition. From clinical perspective, 43 degrees C heat therapeutic regime promises to selectively enhance descending inhibition that is accompanied by improvement of motor dysfunction in PD. (c) 2020 IBRO. Published by Elsevier Ltd. All rights reserved.
Subject: Parkinson's disease
muscle pain
endogenous descending control of pain
thalamic 'nociceptive discriminator'
dopamine
INDUCED MUSCLE NOCICEPTION
BASAL GANGLIA
INTRASTRIATAL 6-HYDROXYDOPAMINE
OXIDATION MECHANISMS
DOPAMINE-RECEPTORS
NUCLEUS-ACCUMBENS
THALAMIC NUCLEI
FOS EXPRESSION
ANIMAL-MODELS
LESIONS
3112 Neurosciences
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