Effects of Heating-needle Stimulation in Restoration of Weakened Descending Inhibition of Nociception in a Rat Model of Parkinson's Disease

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dc.contributor.author Lei, Jing
dc.contributor.author Ye, Gang
dc.contributor.author Pertovaara, Antti
dc.contributor.author You, Hao-Jun
dc.date.accessioned 2021-08-02T22:46:44Z
dc.date.available 2021-12-18T03:45:25Z
dc.date.issued 2020-08-01
dc.identifier.citation Lei , J , Ye , G , Pertovaara , A & You , H-J 2020 , ' Effects of Heating-needle Stimulation in Restoration of Weakened Descending Inhibition of Nociception in a Rat Model of Parkinson's Disease ' , Neuroscience , vol. 440 , pp. 249-266 . https://doi.org/10.1016/j.neuroscience.2020.05.043
dc.identifier.other PURE: 143405756
dc.identifier.other PURE UUID: 087ae70a-bea0-45c3-96d2-4f4d3134a470
dc.identifier.other WOS: 000548211200005
dc.identifier.other ORCID: /0000-0002-8590-7220/work/89114852
dc.identifier.uri http://hdl.handle.net/10138/332767
dc.description.abstract Here we investigated variations of endogenous descending modulation of nociception and therapeutic effects of intramuscular (i.m.) heating-needle stimulation in early stage of Parkinson's disease (PD) induced by unilateral microinjection of 3.5 mu l of 2.5 mu g/mu l 6-hydroxydopamine into the rat striatum. Paw withdrawal reflexes to noxious mechanical and heat stimuli in PD rats with and without exposure to i.m. 5.8% saline induced muscle nociception were evaluated. Experimental PD had no influence on mechanical or heat sensitivity in the baseline condition, whereas descending facilitation was stronger and descending inhibition was weaker in PD rats than vehicle-treated or naive rats during muscle nociception (P <0.05). Striatal administration of 5 mu g of dopamine failed to reverse the PD-associated changes in descending facilitation or inhibition, whereas dopamine in the thalamic mediodorsal (MD) nucleus and ventromedial (VM) nucleus significantly decreased the increase in descending facilitation and reversed the attenuation in descending inhibition, respectively (P <0.05). I.m. 43 degrees C of heating-needle stimulation had no effects on the enhanced descending facilitation in PD rats, but it markedly increased descending inhibition and reversed the increase in the number of apomorphine-induced body rotations (P <0.05), which effects were dose-dependently attenuated by raclopride, a dopamine 2 receptor antagonist, in the thalamic VM nucleus (P <0.05). The results indicate that the early-stage PD is associated with enhanced descending facilitation and weakened descending inhibition. From clinical perspective, 43 degrees C heat therapeutic regime promises to selectively enhance descending inhibition that is accompanied by improvement of motor dysfunction in PD. (c) 2020 IBRO. Published by Elsevier Ltd. All rights reserved. en
dc.format.extent 18
dc.language.iso eng
dc.relation.ispartof Neuroscience
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Parkinson's disease
dc.subject muscle pain
dc.subject endogenous descending control of pain
dc.subject thalamic 'nociceptive discriminator'
dc.subject dopamine
dc.subject BASAL GANGLIA
dc.subject ANIMAL-MODELS
dc.subject LESIONS
dc.subject 3112 Neurosciences
dc.title Effects of Heating-needle Stimulation in Restoration of Weakened Descending Inhibition of Nociception in a Rat Model of Parkinson's Disease en
dc.type Article
dc.contributor.organization Medicum
dc.contributor.organization Department of Physiology
dc.contributor.organization Faculty of Medicine
dc.contributor.organization University of Helsinki
dc.contributor.organization Antti Pertovaara / Principal Investigator
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.neuroscience.2020.05.043
dc.relation.issn 0306-4522
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion

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