Clinical significance of tumor-stroma ratio in head and neck cancer : a systematic review and meta-analysis

Show full item record



Permalink

http://hdl.handle.net/10138/332773

Citation

Almangush , A , Alabi , R O , Troiano , G , Coletta , R D , Salo , T , Pirinen , M , Mäkitie , A A & Leivo , I 2021 , ' Clinical significance of tumor-stroma ratio in head and neck cancer : a systematic review and meta-analysis ' , BMC Cancer , vol. 21 , no. 1 , 480 . https://doi.org/10.1186/s12885-021-08222-8

Title: Clinical significance of tumor-stroma ratio in head and neck cancer : a systematic review and meta-analysis
Author: Almangush, Alhadi; Alabi, Rasheed Omobolaji; Troiano, Giuseppe; Coletta, Ricardo D.; Salo, Tuula; Pirinen, Matti; Mäkitie, Antti A.; Leivo, Ilmo
Contributor: University of Helsinki, HUS Head and Neck Center
University of Helsinki, HUSLAB
University of Helsinki, Centre of Excellence in Complex Disease Genetics
University of Helsinki, HUS Head and Neck Center
University of Helsinki, University of Turku
Date: 2021-04-30
Language: eng
Number of pages: 8
Belongs to series: BMC Cancer
ISSN: 1471-2407
URI: http://hdl.handle.net/10138/332773
Abstract: Background The clinical significance of tumor-stroma ratio (TSR) has been examined in many tumors. Here we systematically reviewed all studies that evaluated TSR in head and neck cancer. Methods Four databases (Scopus, Medline, PubMed and Web of Science) were searched using the term tumo(u)r-stroma ratio. The preferred reporting items for systematic reviews and meta-analyses (PRISMA) were followed. Results TSR was studied in nine studies of different subsites (including cohorts of nasopharyngeal, oral, laryngeal and pharyngeal carcinomas). In all studies, TSR was evaluated using hematoxylin and eosin staining. Classifying tumors based on TSR seems to allow for identification of high-risk cases. In oral cancer, specifically, our meta-analysis showed that TSR is significantly associated with both cancer-related mortality (HR 2.10, 95%CI 1.56-2.84) and disease-free survival (HR 1.84, 95%CI 1.38-2.46). Conclusions The assessment of TSR has a promising prognostic value and can be implemented with minimum efforts in routine head and neck pathology.
Subject: Head and neck cancer
Tumor-stroma ratio
Tumor-stroma
Clinical relevance
Marker
Systematic review and meta-analysis
SQUAMOUS-CELL CARCINOMA
INDEPENDENT PREDICTOR
SURVIVAL
3122 Cancers
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
Clinical_signif ... view_and_meta_analysis.pdf 1.058Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record