3D Printing of Drug Nanocrystals for Film Formulations

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http://hdl.handle.net/10138/332789

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Germini , G & Peltonen , L 2021 , ' 3D Printing of Drug Nanocrystals for Film Formulations ' , Molecules , vol. 26 , no. 13 , 3941 . https://doi.org/10.3390/molecules26133941

Title: 3D Printing of Drug Nanocrystals for Film Formulations
Author: Germini, Giorgia; Peltonen, Leena
Contributor: University of Helsinki, Division of Pharmaceutical Chemistry and Technology
Date: 2021-07
Language: eng
Number of pages: 12
Belongs to series: Molecules
ISSN: 1420-3049
URI: http://hdl.handle.net/10138/332789
Abstract: The aim of the study was to prepare indomethacin nanocrystal-loaded, 3D-printed, fast-dissolving oral polymeric film formulations. Nanocrystals were produced by the wet pearl milling technique, and 3D printing was performed by the semi-solid extrusion method. Hydroxypropyl methyl cellulose (HPMC) was the film-forming polymer, and glycerol the plasticizer. In-depth physicochemical characterization was made, including solid-state determination, particle size and size deviation analysis, film appearance evaluation, determination of weight variation, thickness, folding endurance, drug content uniformity, and disintegration time, and drug release testing. In drug nanocrystal studies, three different stabilizers were tested. Poloxamer F68 produced the smallest and most homogeneous particles, with particle size values of 230 nm and PI values below 0.20, and was selected as a stabilizer for the drug-loaded film studies. In printing studies, the polymer concentration was first optimized with drug-free formulations. The best mechanical film properties were achieved for the films with HPMC concentrations of 2.85% (w/w) and 3.5% (w/w), and these two HPMC levels were selected for further drug-loaded film studies. Besides, in the drug-loaded film printing studies, three different drug levels were tested. With the optimum concentration, films were flexible and homogeneous, disintegrated in 1 to 2.5 min, and released the drug in 2-3 min. Drug nanocrystals remained in the nano size range in the polymer films, particle sizes being in all film formulations from 300 to 500 nm. When the 3D-printed polymer films were compared to traditional film-casted polymer films, the physicochemical behavior and pharmaceutical performance of the films were very similar. As a conclusion, 3D printing of drug nanocrystals in oral polymeric film formulations is a very promising option for the production of immediate-release improved- solubility formulations.
Subject: 3D printing
film formulation
nanocrystals
polymer
poor solubility
semi-solid extrusion
wet milling
CRITICAL MATERIAL ATTRIBUTES
FAST DISSOLVING FILMS
POORLY SOLUBLE DRUGS
STRIP FILMS
HYDROXYPROPYL METHYLCELLULOSE
DELIVERY
RELEASE
NANOSUSPENSIONS
ITRACONAZOLE
IMPACT
317 Pharmacy
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