Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species

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dc.contributor.author Petersen, Anders Ø.
dc.contributor.author Julienne, Hanna
dc.contributor.author Hyötyläinen, Tuulia
dc.contributor.author Sen, Partho
dc.contributor.author Fan, Yong
dc.contributor.author Pedersen, Helle Krogh
dc.contributor.author Jäntti, Sirkku
dc.contributor.author Hansen, Tue H.
dc.contributor.author Nielsen, Trine
dc.contributor.author Jørgensen, Torben
dc.contributor.author Hansen, Torben
dc.contributor.author Myers, Pernille Neve
dc.contributor.author Nielsen, H. Bjørn
dc.contributor.author Ehrlich, S. Dusko
dc.contributor.author Orešič, Matej
dc.contributor.author Pedersen, Oluf
dc.date.accessioned 2021-08-03T11:45:01Z
dc.date.available 2021-08-03T11:45:01Z
dc.date.issued 2021-06-24
dc.identifier.citation Petersen , A Ø , Julienne , H , Hyötyläinen , T , Sen , P , Fan , Y , Pedersen , H K , Jäntti , S , Hansen , T H , Nielsen , T , Jørgensen , T , Hansen , T , Myers , P N , Nielsen , H B , Ehrlich , S D , Orešič , M & Pedersen , O 2021 , ' Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species ' , Scientific Reports , vol. 11 , no. 1 , 13252 . https://doi.org/10.1038/s41598-021-91482-y
dc.identifier.other PURE: 167150800
dc.identifier.other PURE UUID: 2e9a84ed-474b-47c4-bab4-6e56bf46fbed
dc.identifier.other WOS: 000670729700029
dc.identifier.uri http://hdl.handle.net/10138/332796
dc.description.abstract Knowledge about in vivo effects of human circulating C-6 hydroxylated bile acids (BAs), also called muricholic acids, is sparse. It is unsettled if the gut microbiome might contribute to their biosynthesis. Here, we measured a range of serum BAs and related them to markers of human metabolic health and the gut microbiome. We examined 283 non-obese and obese Danish adults from the MetaHit study. Fasting concentrations of serum BAs were quantified using ultra-performance liquid chromatography-tandem mass-spectrometry. The gut microbiome was characterized with shotgun metagenomic sequencing and genome-scale metabolic modeling. We find that tauro- and glycohyocholic acid correlated inversely with body mass index (P = 4.1e-03, P = 1.9e-05, respectively), waist circumference (P = 0.017, P = 1.1e-04, respectively), body fat percentage (P = 2.5e-03, P = 2.3e-06, respectively), insulin resistance (P = 0.051, P = 4.6e-4, respectively), fasting concentrations of triglycerides (P = 0.06, P = 9.2e-4, respectively) and leptin (P = 0.067, P = 9.2e-4). Tauro- and glycohyocholic acids, and tauro-a-muricholic acid were directly linked with a distinct gut microbial community primarily composed of Clostridia species (P = 0.037, P = 0.013, P = 0.027, respectively). We conclude that serum conjugated C-6-hydroxylated BAs associate with measures of human metabolic health and gut communities of Clostridia species. The findings merit preclinical interventions and human feasibility studies to explore the therapeutic potential of these BAs in obesity and type 2 diabetes. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof Scientific Reports
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject MICROBIOME
dc.subject RECEPTOR
dc.subject SAMPLES
dc.subject IMPACT
dc.subject BLOOD
dc.subject 317 Pharmacy
dc.title Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species en
dc.type Article
dc.contributor.organization Division of Pharmaceutical Chemistry and Technology
dc.contributor.organization Drug Research Program
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1038/s41598-021-91482-y
dc.relation.issn 2045-2322
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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