Viral RNA Metagenomics of Hyalomma Ticks Collected from Dromedary Camels in Makkah Province, Saudi Arabia

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Zakham , F , Albalawi , A E , Alanazi , A D , Phuoc Truong Nguyen , Alouffi , A S , Alaoui , A , Sironen , T , Smura , T & Vapalahti , O 2021 , ' Viral RNA Metagenomics of Hyalomma Ticks Collected from Dromedary Camels in Makkah Province, Saudi Arabia ' , Viruses (Basel) , vol. 13 , no. 7 , 1396 . https://doi.org/10.3390/v13071396

Title: Viral RNA Metagenomics of Hyalomma Ticks Collected from Dromedary Camels in Makkah Province, Saudi Arabia
Author: Zakham, Fathiah; Albalawi, Aishah E.; Alanazi, Abdullah D.; Phuoc Truong Nguyen; Alouffi, Abdulaziz S.; Alaoui, Altaf; Sironen, Tarja; Smura, Teemu; Vapalahti, Olli
Contributor organization: Helsinki One Health (HOH)
Veterinary Biosciences
Department of Virology
Medicum
Faculty of Pharmacy
Viral Zoonosis Research Unit
Emerging Infections Research Group
HUSLAB
HUS Diagnostic Center
Veterinary Microbiology and Epidemiology
Olli Pekka Vapalahti / Principal Investigator
Date: 2021-07
Language: eng
Number of pages: 13
Belongs to series: Viruses (Basel)
ISSN: 1999-4915
DOI: https://doi.org/10.3390/v13071396
URI: http://hdl.handle.net/10138/332863
Abstract: Arthropod-borne infections are a medical and economic threat to humans and livestock. Over the last three decades, several unprecedented viral outbreaks have been recorded in the Western part of the Arabian Peninsula. However, little is known about the circulation and diversity of arthropod-borne viruses in this region. To prepare for new outbreaks of vector-borne diseases, it is important to detect which viruses circulate in each vector population. In this study, we used a metagenomics approach to characterize the RNA virome of ticks infesting dromedary camels (Camelus dromedaries) in Makkah province, Saudi Arabia. Two hundred ticks of species Hyalomma dromedarii (n = 196) and Hyalomma impeltatum (n = 4) were collected from the Alkhurma district in Jeddah and Al-Taif city. Virome analysis showed the presence of several tick-specific viruses and tick-borne viruses associated with severe illness in humans. Some were identified for the first time in the Arabian Peninsula. The human disease-associated viruses detected included Crimean Congo Hemorrhagic fever virus and Tamdy virus (family Nairoviridae), Guertu virus (family Phenuiviridae), and a novel coltivirus that shares similarities with Tarumizu virus, Tai forest reovirus and Kundal virus (family Reoviridae). Furthermore, Alkhurma hemorrhagic virus (Flaviviridae) was detected in two tick pools by specific qPCR. In addition, tick-specific viruses in families Phenuiviridae (phleboviruses), Iflaviridae, Chuviridae, Totiviridae and Flaviviridae (Pestivirus) were detected. The presence of human pathogenetic viruses warrants further efforts in tick surveillance, xenosurveillence, vector control, and sero-epidemiological investigations in human and animal populations to predict, contain and mitigate future outbreaks in the region.
Subject: virome analysis
Hyalomma dromedarii
dromedary camels
province of Makkah
Saudi Arabia
arboviruses
tick-borne diseases
HEMORRHAGIC-FEVER VIRUS
COMPLEX
TAMDY
11832 Microbiology and virology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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