TRPV Protein Family-From Mechanosensing to Cancer Invasion

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http://hdl.handle.net/10138/332866

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Karki , T & Tojkander , S 2021 , ' TRPV Protein Family-From Mechanosensing to Cancer Invasion ' , Biomolecules , vol. 11 , no. 7 , 1019 . https://doi.org/10.3390/biom11071019

Title: TRPV Protein Family-From Mechanosensing to Cancer Invasion
Author: Karki, Tytti; Tojkander, Sari
Contributor organization: Helsinki One Health (HOH)
Biosciences
Soluvälitteiset voimat syöpäsolujen invaasiossa
Departments of Faculty of Veterinary Medicine
Veterinary Biosciences
Date: 2021-07
Language: eng
Number of pages: 23
Belongs to series: Biomolecules
ISSN: 2218-273X
DOI: https://doi.org/10.3390/biom11071019
URI: http://hdl.handle.net/10138/332866
Abstract: Biophysical cues from the cellular microenvironment are detected by mechanosensitive machineries that translate physical signals into biochemical signaling cascades. At the crossroads of extracellular space and cell interior are located several ion channel families, including TRP family proteins, that are triggered by mechanical stimuli and drive intracellular signaling pathways through spatio-temporally controlled Ca2+-influx. Mechanosensitive Ca2+-channels, therefore, act as critical components in the rapid transmission of physical signals into biologically compatible information to impact crucial processes during development, morphogenesis and regeneration. Given the mechanosensitive nature of many of the TRP family channels, they must also respond to the biophysical changes along the development of several pathophysiological conditions and have also been linked to cancer progression. In this review, we will focus on the TRPV, vanilloid family of TRP proteins, and their connection to cancer progression through their mechanosensitive nature.
Subject: TRPV
mechanosensing
cancer
invasion
POTENTIAL VANILLOID 2
CATION CHANNEL TRPV4
ION-CHANNEL
PROSTATE-CANCER
TUMOR-GROWTH
CAPSAICIN-RECEPTOR
CA2+ INFLUX
OSMOSENSORY TRANSDUCTION
CLINICAL-SIGNIFICANCE
THERAPEUTIC TARGET
1182 Biochemistry, cell and molecular biology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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