Copper-Silver Nanohybrids: SARS-CoV-2 Inhibitory Surfaces

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http://hdl.handle.net/10138/332871

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Abdelrehiem , D A M , Kareinen , L , Kivistö , I , Aaltonen , K , Virtanen , J M E , Ge , Y & Sironen , T 2021 , ' Copper-Silver Nanohybrids: SARS-CoV-2 Inhibitory Surfaces ' , Nanomaterials , vol. 11 , no. 7 , 1820 . https://doi.org/10.3390/nano11071820

Title: Copper-Silver Nanohybrids: SARS-CoV-2 Inhibitory Surfaces
Author: Abdelrehiem, Dina Ahmed Mosselhy; Kareinen, Lauri; Kivistö, Ilkka; Aaltonen, Kirsi; Virtanen, Jenni Maaret Elina; Ge, Yanling; Sironen, Tarja
Contributor: University of Helsinki, Helsinki One Health (HOH)
University of Helsinki, Veterinary Biosciences
University of Helsinki, Department of Virology
University of Helsinki, Department of Virology
University of Helsinki, Department of Virology
University of Helsinki, Helsinki One Health (HOH)
Date: 2021-07-13
Language: eng
Number of pages: 13
Belongs to series: Nanomaterials
ISSN: 2079-4991
URI: http://hdl.handle.net/10138/332871
Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a severe health threat. The COVID-19 infections occurring in humans and animals render human-animal interfaces hot spots for spreading the pandemic. Lessons from the past point towards the antiviral properties of copper formulations; however, data showing the "contact-time limit" surface inhibitory efficacy of copper formulations to contain SARS-CoV-2 are limited. Here, we show the rapid inhibition of SARS-CoV-2 after only 1 and 5 min on two different surfaces containing copper-silver (Cu-Ag) nanohybrids. We characterized the nanohybrids' powder and surfaces using a series of sophisticated microscopy tools, including transmission and scanning electron microscopes (TEM and SEM) and energy-dispersive X-ray spectroscopy (EDX). We used culturing methods to demonstrate that Cu-Ag nanohybrids with high amounts of Cu (similar to 65 and 78 wt%) and lower amounts of Ag (similar to 7 and 9 wt%) inhibited SARS-CoV-2 efficiently. Collectively, the present work reveals the rapid SARS-CoV-2 surface inhibition and the promising application of such surfaces to break the SARS-CoV-2 transmission chain. For example, such applications could be invaluable within a hospital or live-stock settings, or any public place with surfaces that people frequently touch (i.e., public transportation, shopping malls, elevators, and door handles) after the precise control of different parameters and toxicity evaluations.
Subject: INACTIVATION
SARS-CoV-2
copper
human-animal interfaces
inhibitory surfaces
nanohybrids
silver
11832 Microbiology and virology
3111 Biomedicine
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