Biohybrid Nanosystems for Cancer Treatment : Merging the Best of Two Worlds

Show full item record



Permalink

http://hdl.handle.net/10138/332934

Citation

Fontana , F , Bartolo , R & Santos , H A 2021 , Biohybrid Nanosystems for Cancer Treatment : Merging the Best of Two Worlds . in F Fontana & HA Santos (eds) , BIO-NANOMEDICINE FOR CANCER THERAPY . Advances in Experimental Medicine and Biology , vol. 1295 , Springer International Publishing AG , Cham , pp. 135-162 . https://doi.org/10.1007/978-3-030-58174-9_7

Title: Biohybrid Nanosystems for Cancer Treatment : Merging the Best of Two Worlds
Author: Fontana, Flavia; Bartolo, Raquel; Santos, Helder A.
Editor: Fontana, F; Santos, HA
Contributor: University of Helsinki, Nanomedicines and Biomedical Engineering
University of Helsinki, Divisions of Faculty of Pharmacy
University of Helsinki, Divisions of Faculty of Pharmacy
Publisher: Springer International Publishing AG
Date: 2021
Language: eng
Number of pages: 28
Belongs to series: BIO-NANOMEDICINE FOR CANCER THERAPY
Belongs to series: Advances in Experimental Medicine and Biology
ISBN: 978-3-030-58173-2
978-3-030-58174-9
URI: http://hdl.handle.net/10138/332934
Abstract: During the last 20+ years, research into the biomedical application of nanotechnology has helped in reshaping cancer treatment. The clinical use of several passively targeted nanosystems resulted in improved quality of care for patients. However, the therapeutic efficacy of these systems is not superior to the original drugs. Moreover, despite extensive investigations into actively targeted nanocarriers, numerous barriers still remain before their successful clinical translation, including sufficient blood-stream circulation time and efficient tumor targeting. The combination of synthetic nanomaterials with biological elements (e.g., cells, cell membranes, and macromolecules) is presently the cutting-edge research in cancer nanotechnology. The features provided by the biological moieties render the particles with prolonged bloodstream circulation time and homotopic targeting to the tumor site. Moreover, cancer cell membranes serve as sources of neoantigens, useful in the formulation of nanovaccines. In this chapter, we will discuss the advantages of biohybrid nanosystems in cancer chemotherapy, immunotherapy, and combined therapy, as well as highlight their preparation methods and clinical translatability.
Subject: Biohybrid
Nanoparticle
Cancer
Immunotherapy
Photothermal therapy
MESENCHYMAL STEM-CELLS
MEMBRANE-CAMOUFLAGED NANOPARTICLES
IN-VIVO BIODISTRIBUTION
RED-BLOOD-CELLS
BIOMIMETIC NANOPARTICLES
POLYMERIC NANOPARTICLES
PHOTOTHERMAL THERAPY
MACROPHAGE-MEMBRANE
TUMOR MICROENVIRONMENT
INTRACELLULAR DELIVERY
317 Pharmacy
221 Nano-technology
318 Medical biotechnology
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
Biohybrid_Nanosystems_for_Cancer_Treatment.pdf 2.340Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record