Association of Circulating Metabolites in Plasma or Serum and Risk of Stroke Meta-analysis From 7 Prospective Cohorts

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http://hdl.handle.net/10138/332953

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Vojinovic , D , Kalaoja , M , Trompet , S , Fischer , K , Shipley , M J , Li , S , Havulinna , A S , Perola , M , Salomaa , V , Yang , Q , Sattar , N , Jousilahti , P , Amin , N , Satizabal , C L , Taba , N , Sabayan , B , Vasan , R S , Ikram , M A , Stott , D J , Ala-Korpela , M , Jukema , J W , Seshadri , S , Kettunen , J , Kivimaki , M , Esko , T & van Duijn , C M 2021 , ' Association of Circulating Metabolites in Plasma or Serum and Risk of Stroke Meta-analysis From 7 Prospective Cohorts ' , Neurology , vol. 96 , no. 8 , pp. E1110-E1123 . https://doi.org/10.1212/WNL.0000000000011236

Title: Association of Circulating Metabolites in Plasma or Serum and Risk of Stroke Meta-analysis From 7 Prospective Cohorts
Author: Vojinovic, Dina; Kalaoja, Marita; Trompet, Stella; Fischer, Krista; Shipley, Martin J.; Li, Shuo; Havulinna, Aki S.; Perola, Markus; Salomaa, Veikko; Yang, Qiong; Sattar, Naveed; Jousilahti, Pekka; Amin, Najaf; Satizabal, Claudia L.; Taba, Nele; Sabayan, Behnam; Vasan, Ramachandran S.; Ikram, M. Arfan; Stott, David J.; Ala-Korpela, Mika; Jukema, J. Wouter; Seshadri, Sudha; Kettunen, Johannes; Kivimaki, Mika; Esko, Tonu; van Duijn, Cornelia M.
Contributor organization: Medicum
Institute for Molecular Medicine Finland
Complex Disease Genetics
University of Helsinki
Date: 2021-02-23
Language: eng
Number of pages: 14
Belongs to series: Neurology
ISSN: 0028-3878
DOI: https://doi.org/10.1212/WNL.0000000000011236
URI: http://hdl.handle.net/10138/332953
Abstract: Objective To conduct a comprehensive analysis of circulating metabolites and incident stroke in large prospective population-based settings. Methods We investigated the association of metabolites with risk of stroke in 7 prospective cohort studies including 1,791 incident stroke events among 38,797 participants in whom circulating metabolites were measured by nuclear magnetic resonance technology. The relationship between metabolites and stroke was assessed with Cox proportional hazards regression models. The analyses were performed considering all incident stroke events and ischemic and hemorrhagic events separately. Results The analyses revealed 10 significant metabolite associations. Amino acid histidine (hazard ratio [HR] per SD 0.90, 95% confidence interval [CI] 0.85, 0.94; p = 4.45 x 10-5), glycolysis-related metabolite pyruvate (HR per SD 1.09, 95% CI 1.04, 1.14; p = 7.45 x 10-4), acute-phase reaction marker glycoprotein acetyls (HR per SD 1.09, 95% CI 1.03, 1.15; p = 1.27 x 10-3), cholesterol in high-density lipoprotein (HDL) 2, and several other lipoprotein particles were associated with risk of stroke. When focused on incident ischemic stroke, a significant association was observed with phenylalanine (HR per SD 1.12, 95% CI 1.05, 1.19; p = 4.13 x 10-4) and total and free cholesterol in large HDL particles. Conclusions We found association of amino acids, glycolysis-related metabolites, acute-phase reaction markers, and several lipoprotein subfractions with the risk of stroke. These findings support the potential of metabolomics to provide new insights into the metabolic changes preceding stroke.
Subject: DENSITY-LIPOPROTEIN TRIGLYCERIDES
PYRUVATE PROTECTS
BLOOD-PRESSURE
LIFETIME RISK
HDL PARTICLES
GENOME-WIDE
METABOLOMICS
CHOLESTEROL
HISTIDINE
MORTALITY
3112 Neurosciences
3124 Neurology and psychiatry
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion


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