Facial Asymmetry in Nonsyndromic and Muenke Syndrome-Associated Unicoronal Synostosis : A 3-Dimensional Study Based on Facial Surfaces Extracted From CT Scans

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http://hdl.handle.net/10138/332979

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Owall , L , Darvann , T A , Hove , H B , Heliövaara , A , Duno , M , Kreiborg , S & Hermann , N 2021 , ' Facial Asymmetry in Nonsyndromic and Muenke Syndrome-Associated Unicoronal Synostosis : A 3-Dimensional Study Based on Facial Surfaces Extracted From CT Scans ' , Cleft Palate - Craniofacial Journal , vol. 58 , no. 6 , pp. 687-696 . https://doi.org/10.1177/1055665620959983

Julkaisun nimi: Facial Asymmetry in Nonsyndromic and Muenke Syndrome-Associated Unicoronal Synostosis : A 3-Dimensional Study Based on Facial Surfaces Extracted From CT Scans
Tekijä: Owall, Louise; Darvann, Tron A.; Hove, Hanne B.; Heliövaara, Arja; Duno, Morten; Kreiborg, Sven; Hermann, Nuno
Tekijän organisaatio: HUS Musculoskeletal and Plastic Surgery
Plastiikkakirurgian yksikkö
Helsinki University Hospital Area
Päiväys: 2021-06
Kieli: eng
Sivumäärä: 10
Kuuluu julkaisusarjaan: Cleft Palate - Craniofacial Journal
ISSN: 1055-6656
DOI-tunniste: https://doi.org/10.1177/1055665620959983
URI: http://hdl.handle.net/10138/332979
Tiivistelmä: Objective: To quantify soft tissue facial asymmetry (FA) in children with nonsyndromic and Muenke syndrome-associated unicoronal synostosis (NS-UCS and MS-UCS), hypothesizing that MS-UCS presents with significantly larger FA than NS-UCS. Design: Retrospective cohort study. Patients and Methods: Twenty-one children (mean age: 0.6 years; range: 0.1-1.4 years) were included in the study (NS-UCS = 14; MS-UCS = 7). From presurgical computed tomography scans, facial surfaces were constructed for analysis. A landmark guided atlas was deformed to match each patient's surface, obtaining spatially detailed left-right point correspondence. Facial asymmetry was calculated in each surface point across the face, as the length (mm) of an asymmetry vector, with its Cartesian components providing 3 directions. Mean FA was calculated for the full face, and the forehead, eye, nose, cheek, mouth, and chin regions. Results: For the full face, a significant difference of 2.4 mm (P = .001) was calculated between the 2 groups, predominately in the transverse direction (1.5 mm; P < .001). The forehead and chin regions presented with the largest significant difference, 3.5 mm (P = .002) and 3.2 mm (P < .001), respectively; followed by the eye (2.4 mm; P = .004), cheek (2.2 mm; P = .004), nose (1.7 mm; P = .001), and mouth (1.4 mm; P = .009) regions. The transverse direction presented with the largest significant difference in the forehead, chin, mouth, and nose regions, the sagittal direction in the cheek region, and the vertical direction in the eye region. Conclusions: Muenke syndrome-associated unicoronal synostosis presented with significantly larger FA in all regions compared to NS-UCS. The largest significant differences were found in the forehead and chin regions, predominantly in the transverse direction.
Avainsanat: facial morphology
synostosis
pediatrics
GROWTH-FACTOR RECEPTOR-3
CRANIOSYNOSTOSIS
MUTATION
EXPANSION
PHENOTYPE
3126 Surgery, anesthesiology, intensive care, radiology
313 Dentistry
Vertaisarvioitu: Kyllä
Tekijänoikeustiedot: cc_by_nc
Pääsyrajoitteet: openAccess
Rinnakkaistallennettu versio: publishedVersion


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