Facial Asymmetry in Nonsyndromic and Muenke Syndrome-Associated Unicoronal Synostosis : A 3-Dimensional Study Based on Facial Surfaces Extracted From CT Scans

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dc.contributor.author Owall, Louise
dc.contributor.author Darvann, Tron A.
dc.contributor.author Hove, Hanne B.
dc.contributor.author Heliövaara, Arja
dc.contributor.author Duno, Morten
dc.contributor.author Kreiborg, Sven
dc.contributor.author Hermann, Nuno
dc.date.accessioned 2021-08-10T06:00:01Z
dc.date.available 2021-08-10T06:00:01Z
dc.date.issued 2021-06
dc.identifier.citation Owall , L , Darvann , T A , Hove , H B , Heliövaara , A , Duno , M , Kreiborg , S & Hermann , N 2021 , ' Facial Asymmetry in Nonsyndromic and Muenke Syndrome-Associated Unicoronal Synostosis : A 3-Dimensional Study Based on Facial Surfaces Extracted From CT Scans ' , Cleft Palate - Craniofacial Journal , vol. 58 , no. 6 , pp. 687-696 . https://doi.org/10.1177/1055665620959983
dc.identifier.other PURE: 167343581
dc.identifier.other PURE UUID: 11ba4509-427c-44cb-8545-b1af74ebdb9d
dc.identifier.other WOS: 000658574700003
dc.identifier.uri http://hdl.handle.net/10138/332979
dc.description.abstract Objective: To quantify soft tissue facial asymmetry (FA) in children with nonsyndromic and Muenke syndrome-associated unicoronal synostosis (NS-UCS and MS-UCS), hypothesizing that MS-UCS presents with significantly larger FA than NS-UCS. Design: Retrospective cohort study. Patients and Methods: Twenty-one children (mean age: 0.6 years; range: 0.1-1.4 years) were included in the study (NS-UCS = 14; MS-UCS = 7). From presurgical computed tomography scans, facial surfaces were constructed for analysis. A landmark guided atlas was deformed to match each patient's surface, obtaining spatially detailed left-right point correspondence. Facial asymmetry was calculated in each surface point across the face, as the length (mm) of an asymmetry vector, with its Cartesian components providing 3 directions. Mean FA was calculated for the full face, and the forehead, eye, nose, cheek, mouth, and chin regions. Results: For the full face, a significant difference of 2.4 mm (P = .001) was calculated between the 2 groups, predominately in the transverse direction (1.5 mm; P < .001). The forehead and chin regions presented with the largest significant difference, 3.5 mm (P = .002) and 3.2 mm (P < .001), respectively; followed by the eye (2.4 mm; P = .004), cheek (2.2 mm; P = .004), nose (1.7 mm; P = .001), and mouth (1.4 mm; P = .009) regions. The transverse direction presented with the largest significant difference in the forehead, chin, mouth, and nose regions, the sagittal direction in the cheek region, and the vertical direction in the eye region. Conclusions: Muenke syndrome-associated unicoronal synostosis presented with significantly larger FA in all regions compared to NS-UCS. The largest significant differences were found in the forehead and chin regions, predominantly in the transverse direction. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof Cleft Palate - Craniofacial Journal
dc.rights cc_by_nc
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject facial morphology
dc.subject synostosis
dc.subject pediatrics
dc.subject GROWTH-FACTOR RECEPTOR-3
dc.subject CRANIOSYNOSTOSIS
dc.subject MUTATION
dc.subject EXPANSION
dc.subject PHENOTYPE
dc.subject 3126 Surgery, anesthesiology, intensive care, radiology
dc.subject 313 Dentistry
dc.title Facial Asymmetry in Nonsyndromic and Muenke Syndrome-Associated Unicoronal Synostosis : A 3-Dimensional Study Based on Facial Surfaces Extracted From CT Scans en
dc.type Article
dc.contributor.organization HUS Musculoskeletal and Plastic Surgery
dc.contributor.organization Plastiikkakirurgian yksikkö
dc.contributor.organization Helsinki University Hospital Area
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1177/1055665620959983
dc.relation.issn 1055-6656
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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