Intracellular delivery of budesonide and polydopamine co-loaded in endosomolytic poly(butyl methacrylate-co-methacrylic acid) grafted acetalated dextran for macrophage phenotype switch from M1 to M2

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Wang , S , Wannasarit , S , Figueiredo , P , Molinaro , G , Ding , Y , Correia , A , Casettari , L , Wiwattanapatapee , R , Hirvonen , J , Liu , D , Li , W & Santos , H A 2021 , ' Intracellular delivery of budesonide and polydopamine co-loaded in endosomolytic poly(butyl methacrylate-co-methacrylic acid) grafted acetalated dextran for macrophage phenotype switch from M1 to M2 ' , Advanced Therapeutics , vol. 4 , no. 1 , 2000058 . https://doi.org/10.1002/adtp.202000058

Title: Intracellular delivery of budesonide and polydopamine co-loaded in endosomolytic poly(butyl methacrylate-co-methacrylic acid) grafted acetalated dextran for macrophage phenotype switch from M1 to M2
Author: Wang, Shiqi; Wannasarit, Saowanee; Figueiredo, Patricia; Molinaro, Giuseppina; Ding, Yaping; Correia, Alexandra; Casettari, Luca; Wiwattanapatapee, Ruedeekorn; Hirvonen, Jouni; Liu, Dongfei; Li, Wei; Santos, Hélder A.
Other contributor: University of Helsinki, Nanomedicines and Biomedical Engineering
University of Helsinki, Nanomedicines and Biomedical Engineering
University of Helsinki, Nanomedicines and Biomedical Engineering
University of Helsinki, Nanomedicines and Biomedical Engineering
University of Helsinki, Drug Research Program
University of Helsinki, Drug Research Program
University of Helsinki, Drug Research Program
University of Helsinki, Helsinki One Health (HOH)






Date: 2021-01
Language: eng
Number of pages: 11
Belongs to series: Advanced Therapeutics
ISSN: 2366-3987
DOI: https://doi.org/10.1002/adtp.202000058
URI: http://hdl.handle.net/10138/333012
Abstract: In this study, a rationally designed nanocomposite (BUDPDA@MAP) composed of polydopamine (PDA) nanoparticle and anti‐inflammatory drug budesonide (BUD) encapsulated in a pH‐responsive endosomolytic polymer (poly(butyl methacrylate‐co‐methacrylic acid) grafted acetalated dextran, denoted by MAP), is proposed. The uniform nanocomposite is prepared using a microfluidic device. At low endosomal pH (5.5), MAP destabilizes the endosomal membranes for the cytoplasmic delivery of PDA, and releases BUD simultaneously, resulting in a greater reactive oxygen species scavenging capability than both the free drug and PDA alone. The combined therapeutic efficacy from PDA and BUD also leads to a successful macrophage phenotype switch from pro‐inflammatory M1 to anti‐inflammatory M2.
Subject: ANTIGEN
ENHANCEMENT
INFLAMMATION
NANOPARTICLES
PEPTIDES
POLYMERS
drug delivery
endosomal escape
macrophage phenotypes
microfluidics
polydopamine
317 Pharmacy
221 Nano-technology
318 Medical biotechnology
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