Chemically Engineered Immune Cell-Derived Microrobots and Biomimetic Nanoparticles : Emerging Biodiagnostic and Therapeutic Tools

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Jahromi , L P , Shahbazi , M-A , Maleki , A , Azadi , A & Santos , H A 2021 , ' Chemically Engineered Immune Cell-Derived Microrobots and Biomimetic Nanoparticles : Emerging Biodiagnostic and Therapeutic Tools ' , Advanced Science , vol. 8 , no. 8 , 2002499 . https://doi.org/10.1002/advs.202002499

Title: Chemically Engineered Immune Cell-Derived Microrobots and Biomimetic Nanoparticles : Emerging Biodiagnostic and Therapeutic Tools
Author: Jahromi, Leila Pourtalebi; Shahbazi, Mohammad-Ali; Maleki, Aziz; Azadi, Amir; Santos, Helder A.
Contributor: University of Helsinki, Nanomedicines and Biomedical Engineering
University of Helsinki, Helsinki One Health (HOH)
Date: 2021-04-21
Language: eng
Number of pages: 70
Belongs to series: Advanced Science
ISSN: 2198-3844
URI: http://hdl.handle.net/10138/333030
Abstract: Over the past decades, considerable attention has been dedicated to the exploitation of diverse immune cells as therapeutic and/or diagnostic cell-based microrobots for hard-to-treat disorders. To date, a plethora of therapeutics based on alive immune cells, surface-engineered immune cells, immunocytes' cell membranes, leukocyte-derived extracellular vesicles or exosomes, and artificial immune cells have been investigated and a few have been introduced into the market. These systems take advantage of the unique characteristics and functions of immune cells, including their presence in circulating blood and various tissues, complex crosstalk properties, high affinity to different self and foreign markers, unique potential of their on-demand navigation and activity, production of a variety of chemokines/cytokines, as well as being cytotoxic in particular conditions. Here, the latest progress in the development of engineered therapeutics and diagnostics inspired by immune cells to ameliorate cancer, inflammatory conditions, autoimmune diseases, neurodegenerative disorders, cardiovascular complications, and infectious diseases is reviewed, and finally, the perspective for their clinical application is delineated.
Subject: artificial dendritic cell and extracellular vesicle
biomimetic drug delivery
engineered immune cell
immune cell membrane
nanomedicine
ANTIGEN-PRESENTING CELLS
NATURAL-KILLER-CELLS
DRUG-DELIVERY-SYSTEMS
MEMBRANE-CAMOUFLAGED NANOPARTICLES
MACROPHAGE-MEDIATED DELIVERY
ISCHEMIA-REPERFUSION INJURY
DENDRITIC CELLS
EXTRACELLULAR VESICLES
T-CELLS
PHOTOTHERMAL THERAPY
116 Chemical sciences
318 Medical biotechnology
221 Nano-technology
317 Pharmacy
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