Proteoglycan binding as proatherogenic function metric of apoB-containing lipoproteins and chronic kidney graft failure
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Steffen , H L M , Anderson , J L C , Poot , M L , Lei , Y , Connelly , M A , Bakker , S J L , Öörni , K & Tietge , U J F 2021 , ' Proteoglycan binding as proatherogenic function metric of apoB-containing lipoproteins and chronic kidney graft failure ' , Journal of Lipid Research , vol. 62 , 100083 . https://doi.org/10.1016/j.jlr.2021.100083
| Title: | Proteoglycan binding as proatherogenic function metric of apoB-containing lipoproteins and chronic kidney graft failure |
| Author: | Steffen, Hannah L. M.; Anderson, Josephine L. C.; Poot, Margot L.; Lei, Yu; Connelly, Margery A.; Bakker, Stephan J. L.; Öörni, Katariina; Tietge, Uwe J. F. |
| Contributor organization: | Molecular and Integrative Biosciences Research Programme Biosciences |
| Date: | 2021 |
| Language: | eng |
| Number of pages: | 9 |
| Belongs to series: | Journal of Lipid Research |
| ISSN: | 0022-2275 |
| DOI: | https://doi.org/10.1016/j.jlr.2021.100083 |
| URI: | http://hdl.handle.net/10138/333229 |
| Abstract: | Lipoprotein-proteoglycan binding is an early key event in atherosclerotic lesion formation and thus conceivably could play a major role in vasculopathy-driven chronic graft failure and cardiovascular mortality in renal transplant recipients. The present study investigated whether lipoproteinproteoglycan binding susceptibility (LPBS) of apoBcontaining lipoproteins and levels of the classical atherosclerosis biomarker LDL-C were associated with cardiovascular mortality (n = 130) and graft failure (n = 73) in 589 renal transplant recipients who were followed up from at least 1 year after transplantation for 9.5 years. At baseline, LPBS was significantly higher in patients who subsequently developed graft failure than in those with a surviving graft (1.68 +/- 0.93 vs. 1.46 +/- 0.49 nmol/mmol, P = 0.001). Cox regression analysis showed an association between LPBS and chronic graft failure in an age-and sex-adjusted model (hazard ratio: 1.45; 95% CI, 1.14-1.85; P = 0.002), but no association was observed with cardiovascular mortality. LDL-C levels were not associated with graft failure or cardiovascular mortality. This study shows that measurement of cholesterol retention outperformed the traditionally used quantitative parameter of LDL-C levels in predicting graft failure, suggesting a higher relevance of proatherogenic function than the quantity of apoBcontaining lipoproteins in chronic kidney graft failure. |
| Subject: |
chronic graft failure
transplant vasculopathy proteoglycans cholesterol atherosclerosis LDL prospective lipoprotein-proteoglycan binding susceptibility cardiovascular mortality kidney transplantation LOW-DENSITY LIPOPROTEINS HUMAN AORTIC PROTEOGLYCANS MUSCLE-CELL PROTEOGLYCANS CHOLESTEROL PARTICLES AFFINITY ATHEROSCLEROSIS COMPLICATIONS AGGREGATION 1182 Biochemistry, cell and molecular biology |
| Peer reviewed: | Yes |
| Rights: | cc_by |
| Usage restriction: | openAccess |
| Self-archived version: | publishedVersion |
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