The effect of recombination on the evolution of a population of Neisseria meningitidis

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dc.contributor.author MacAlasdair, Neil
dc.contributor.author Pesonen, Maiju
dc.contributor.author Brynildsrud, Ola
dc.contributor.author Eldholm, Vegard
dc.contributor.author Kristiansen, Paul A.
dc.contributor.author Corander, Jukka
dc.contributor.author Caugant, Dominique A.
dc.contributor.author Bentley, Stephen D.
dc.date.accessioned 2021-08-17T08:09:01Z
dc.date.available 2021-08-17T08:09:01Z
dc.date.issued 2021-07
dc.identifier.citation MacAlasdair , N , Pesonen , M , Brynildsrud , O , Eldholm , V , Kristiansen , P A , Corander , J , Caugant , D A & Bentley , S D 2021 , ' The effect of recombination on the evolution of a population of Neisseria meningitidis ' , Genome Research , vol. 31 . https://doi.org/10.1101/gr.264465.120
dc.identifier.other PURE: 167655143
dc.identifier.other PURE UUID: f7cc507e-bbc9-4902-b05c-1778ff90d60e
dc.identifier.other WOS: 000679842500001
dc.identifier.uri http://hdl.handle.net/10138/333237
dc.description.abstract Neisseria meningitidis (the meningococcus) is a major human pathogen with a history of high invasive disease burden, particularly in sub-Saharan Africa. Our current understanding of the evolution of meningococcal genomes is limited by the rarity of large-scale genomic population studies and lack of in-depth investigation of the genomic events associated with routine pathogen transmission. Here, we fill this knowledge gap by a detailed analysis of 2839 meningococcal genomes obtained through a carriage study of over 50,000 samples collected systematically in Burkina Faso, West Africa, before, during, and after the serogroup A vaccine rollout, 2009-2012. Our findings indicate that the meningococcal genome is highly dynamic, with highly recombinant loci and frequent gene sharing across deeply separated lineages in a structured population. Furthermore, our findings illustrate how population structure can correlate with genome flexibility, as some lineages in Burkina Faso are orders of magnitude more recombinant than others. We also examine the effect of selection on the population, in particular how it is correlated with recombination. We find that recombination principally acts to prevent the accumulation of deleterious mutations, although we do also find an example of recombination acting to speed the adaptation of a gene. In general, we show the importance of recombination in the evolution of a geographically expansive population with deep population structure in a short timescale. This has important consequences for our ability to both foresee the outcomes of vaccination programs and, using surveillance data, predict when lineages of the meningococcus are likely to become a public health concern. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof Genome Research
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject MULTIPLE SEQUENCE ALIGNMENT
dc.subject MENINGOCOCCAL CARRIAGE
dc.subject EPIDEMIC MENINGITIS
dc.subject IDENTIFICATION
dc.subject BELT
dc.subject ASSOCIATION
dc.subject SELECTION
dc.subject ELEMENTS
dc.subject IMPACT
dc.subject MODEL
dc.subject 1184 Genetics, developmental biology, physiology
dc.title The effect of recombination on the evolution of a population of Neisseria meningitidis en
dc.type Article
dc.contributor.organization Helsinki Institute for Information Technology
dc.contributor.organization Jukka Corander / Principal Investigator
dc.contributor.organization Department of Mathematics and Statistics
dc.contributor.organization Biostatistics Helsinki
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1101/gr.264465.120
dc.relation.issn 1088-9051
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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