A comparative analysis of parechovirus protein structures with other picornaviruses

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dc.contributor.author Domanska, Ausra
dc.contributor.author Guryanov, Sergey
dc.contributor.author Butcher, Sarah J.
dc.date.accessioned 2021-08-17T08:21:01Z
dc.date.available 2021-08-17T08:21:01Z
dc.date.issued 2021-07-28
dc.identifier.citation Domanska , A , Guryanov , S & Butcher , S J 2021 , ' A comparative analysis of parechovirus protein structures with other picornaviruses ' , Open biology , vol. 11 , no. 7 , 210008 . https://doi.org/10.1098/rsob.210008
dc.identifier.other PURE: 167655440
dc.identifier.other PURE UUID: 3ce5c351-392d-424c-b09a-43bdd879a0f9
dc.identifier.other WOS: 000679964500001
dc.identifier.other ORCID: /0000-0002-3772-6003/work/98609748
dc.identifier.other ORCID: /0000-0001-7060-5871/work/98610038
dc.identifier.other ORCID: /0000-0003-3058-5460/work/98610474
dc.identifier.uri http://hdl.handle.net/10138/333238
dc.description.abstract Parechoviruses belong to the genus Parechovirus within the family Picornaviridae and are non-enveloped icosahedral viruses with a single-stranded RNA genome. Parechoviruses include human and animal pathogens classified into six species. Those that infect humans belong to the Parechovirus A species and can cause infections ranging from mild gastrointestinal or respiratory illness to severe neonatal sepsis. There are no approved antivirals available to treat parechovirus (nor any other picornavirus) infections. In this parechovirus review, we focus on the cleaved protein products resulting from the polyprotein processing after translation comparing and contrasting their known or predicted structures and functions to those of other picornaviruses. The review also includes our original analysis from sequence and structure prediction. This review highlights significant structural differences between parechoviral and other picornaviral proteins, suggesting that parechovirus drug development should specifically be directed to parechoviral targets. en
dc.format.extent 14
dc.language.iso eng
dc.relation.ispartof Open biology
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject picornavirus
dc.subject parechovirus
dc.subject structure
dc.subject RNA stem-loop
dc.subject function
dc.subject POLIOVIRUS POLYPEPTIDE 3CD
dc.subject DEPENDENT RNA-POLYMERASE
dc.subject COMMON COLD VIRUS
dc.subject CRYSTAL-STRUCTURE
dc.subject MEMBRANE PERMEABILIZATION
dc.subject GENOMIC CHARACTERIZATION
dc.subject ENTEROVIRUS REPLICATION
dc.subject NUCLEOTIDE-SEQUENCE
dc.subject ATP HYDROLYSIS
dc.subject LJUNGAN VIRUS
dc.subject 1182 Biochemistry, cell and molecular biology
dc.title A comparative analysis of parechovirus protein structures with other picornaviruses en
dc.type Review Article
dc.contributor.organization Institute of Biotechnology
dc.contributor.organization Macromolecular structure and function
dc.contributor.organization Molecular and Integrative Biosciences Research Programme
dc.contributor.organization Biosciences
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1098/rsob.210008
dc.relation.issn 2046-2441
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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