Detrended fluctuation analysis in the presurgical evaluation of parietal lobe epilepsy patients

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http://hdl.handle.net/10138/333290

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Auno , S , Lauronen , L , Wilenius , J , Peltola , M , Vanhatalo , S & Palva , J M 2021 , ' Detrended fluctuation analysis in the presurgical evaluation of parietal lobe epilepsy patients ' , Clinical Neurophysiology , vol. 132 , no. 7 , pp. 1515-1525 . https://doi.org/10.1016/j.clinph.2021.03.041

Title: Detrended fluctuation analysis in the presurgical evaluation of parietal lobe epilepsy patients
Author: Auno, Sami; Lauronen, Leena; Wilenius, Juha; Peltola, Maria; Vanhatalo, Sampsa; Palva, J. Matias
Contributor: University of Helsinki, Neuroscience Center
University of Helsinki, HUS Medical Imaging Center
University of Helsinki, HUSLAB
University of Helsinki, HUS Medical Imaging Center
University of Helsinki, HUS Medical Imaging Center
University of Helsinki, Matias Palva / Principal Investigator
Date: 2021-07
Language: eng
Number of pages: 11
Belongs to series: Clinical Neurophysiology
ISSN: 1388-2457
URI: http://hdl.handle.net/10138/333290
Abstract: Objective: To examine the usability of long-range temporal correlations (LRTCs) in non-invasive localization of the epileptogenic zone (EZ) in refractory parietal lobe epilepsy (RPLE) patients. Methods: We analyzed 10 RPLE patients who had presurgical MEG and underwent epilepsy surgery. We quantified LRTCs with detrended fluctuation analysis (DFA) at four frequency bands for 200 cortical regions estimated using individual source models. We correlated individually the DFA maps to the distance from the resection area and from cortical locations of interictal epileptiform discharges (IEDs). Additionally, three clinical experts inspected the DFA maps to visually assess the most likely EZ locations. Results: The DFA maps correlated with the distance to resection area in patients with type II focal cortical dysplasia (FCD) (p < 0:05), but not in other etiologies. Similarly, the DFA maps correlated with the IED locations only in the FCD II patients. Visual analysis of the DFA maps showed high interobserver agreement and accuracy in FCD patients in assigning the affected hemisphere and lobe. Conclusions: Aberrant LRTCs correlate with the resection areas and IED locations. Significance: This methodological pilot study demonstrates the feasibility of approximating cortical LRTCs from MEG that may aid in the EZ localization and provide new non-invasive insight into the presurgical evaluation of epilepsy. (c) 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Subject: Epilepsy surgery
MEG
Detrended fluctuation analysis
Long-range temporal correlation
RANGE TEMPORAL CORRELATIONS
PHASE SYNCHRONIZATION
NEURONAL AVALANCHES
SCALING BEHAVIOR
EEG
DYNAMICS
OSCILLATIONS
REMISSION
PATTERNS
3112 Neurosciences
3126 Surgery, anesthesiology, intensive care, radiology
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